Results 41 to 50 of about 26,112,494 (338)

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. [PDF]

, 2020
Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γc).
De Paula, Viviane S, Garcia, K Christopher, Glassman, Caleb R, Jude, Kevin M, Nerli, Santrupti, Sgourakis, Nikolaos G   +5 more
core   +1 more source

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.

Immunity, 2007
Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory ...
A. Laurence, C. Tato, Todd S. Davidson, Y. Kanno, Zhi Chen, Zhengju Yao, R. Blank, F. Meylan, R. Siegel, L. Hennighausen, E. Shevach, J. O’Shea   +11 more
semanticscholar   +1 more source

Biological therapy in the treatment of melanoma [PDF]

, 2018
Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable ...
Benea, Vasile, Georgescu, Simona Roxana, Ghita, Ela, Ioghen, Mihaela Roxana, Ion, Alexandra-Florentina, Mitran, Cristina-Iulia, Mitran, Madalina-Irina, Sarbu, Maria Isabela, Tampa, Mircea   +8 more
core   +3 more sources

Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma

OncoImmunology, 2022
Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA.
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger, Niels Halama   +8 more
doaj   +1 more source

A Novel Technique for the Generation of Substantial Numbers of Functional Resident T Cells from Kidney Tissue

Cells, 2022
Studying functionality and antigen-specificity of resident kidney T cells derived from a kidney biopsy is hampered by the lack of sufficient numbers of T cells obtained by the standard method of enzymatic tissue dissociation.
Michiel G. H. Betjes, Frederique Prevoo, Thierry P. P. van den Bosch, Mariska Klepper, Nicolle H. R. Litjens   +4 more
doaj   +1 more source

Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes

Journal of Experimental Medicine, 1982
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from cancer patients or normal individuals resulted in expression of cytotoxicity toward 20 of 21 natural killer (NK)-resistant fresh ...
E. Grimm, A. Mazumder, Hua Zhang, S. Rosenberg   +3 more
semanticscholar   +1 more source

FEATURES OF CEREBRAL HEMODYNAMICS AND MANIFESTATIONS OF HEPATIC ENCEPHALOPATHY IN CIRRHOSIS OF VIRAL ETIOLOGY AT DIFFERENT COMPENSATION STAGES WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION

Рациональная фармакотерапия в кардиологии, 2017
Aim. To study the features of the parameters of cerebral hemodynamics in extra and intracranial regions in viral hepatic cirrhosis A, B, C classes according to Child-Pugh with different serum levels of interleukin-2, interleukin-6 and tumor necrosis ...
V. E. Kulikov, T. A. Emelina, O. G. Kazakova, K. V. Nikolaevа, M. E. Hapman, M. A. Tonеeva   +5 more
doaj   +1 more source

An Antibody Targeting Fibroblast Activation Protein Simultaneously Fused to Interleukin-2 and Tumor Necrosis Factor Selectively Localizes to Neoplastic Lesions

Antibodies, 2023
The delivery of specific cytokine payloads to a neoplastic environment employing antibodies able to selectively accumulate at the tumor site represents an attractive strategy to stimulate an immune response to cancer.
Eleonora Prodi, Claudia Comacchio, Ettore Gilardoni, Cesare Di Nitto, Emanuele Puca, Dario Neri, Roberto De Luca   +6 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES

Рациональная фармакотерапия в кардиологии, 2017
Aim. To study possible variants of changes in structural and functional parameters of central hemodynamics in liver cirrhosis classes A, B, C (Child– Pugh) to improve the early diagnostics of extrahepatic complications.Material and methods. Parameters of
V. E Kulikov, T. A. Emelina, O. G. Kazakova, K. V. Nikolaevа, M. E. Hapman, M. A. Tonеeva   +5 more
doaj   +1 more source