Results 21 to 30 of about 26,112,494 (338)

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

Journal of Experimental Medicine, 1998
Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of autoreactive T cells recognizing tissue-specific antigens.
A. Thornton, E. Shevach
semanticscholar   +1 more source

Label-free, single molecule detection of cytokines using optical microcavities [PDF]

, 2007
Interleukin-2 (IL2) is a cytokine that regulates T-cell growth and is used in cancer therapies. By sensitizing a microcavity sensor surface with anti-IL2 and monitoring the resonant frequency, single molecules of IL2 can be ...
Armani, Andrea M., Fraser, Scott E., Vahala, Kerry J.   +2 more
core   +1 more source

Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients

Cells, 2019
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). T helper (Th) 17 lymphocytes play a role in the pathogenesis of MS.
Alessia Capone, Manuela Bianco, Gabriella Ruocco, Marco De Bardi, Luca Battistini, Serena Ruggieri, Claudio Gasperini, Diego Centonze, Claudio Sette, Elisabetta Volpe   +9 more
doaj   +1 more source

Effects of interleukin-2 in immunostimulation and immunosuppression

Journal of Experimental Medicine, 2019
Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects.
Jonathan G. Pol, P. Caudana, J. Paillet, E. Piaggio, G. Kroemer   +4 more
semanticscholar   +1 more source

Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.

Blood Advances, 2017
Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults.
A. Hayden, Molly M. Lin, Sujin Park, M. Pudek, Marion Schneider, M. Jordan, A. Mattman, Luke Y. C. Chen   +7 more
semanticscholar   +1 more source

Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb [PDF]

, 1999
Background. We previously reported the association among donor leukocyte chimerism, apoptosis of presumedly IL-2-deficient graft-infiltrating host cells, and the spontaneous donor-specific tolerance induced by liver but not heart allografts in mice ...
Angus W. Thomson, Aust, Bishop, Bishop, Buhlmann, Cohn, Cuiping Zhong, Dai, Demetris, Durie, Effros, Ehl, Fu, Hancock, Inaba, Janeway, Jenkins, John J. Fung, Kneitz, Konieczny, Larsen, Larsen, Lenschow, Lina Lu, Lu, Lu, Lu, Lu, Lu, Markees, Matzinger, Meyer, Morecki, Murase, Murase, Murase, Niimi, Ohashi, Ohashi, Parker, Picker, Qian, Qian, Rafaeli, Rastellini, Sayegh, Schwartz, Shiguang Qian, Starzl, Starzl, Starzl, Starzl, Sun, Taniguchi, Thomas E. Starzl, Thomson, Thomson, Van Parijs, Wei Li, Wekerle, Willerford, Zinkernagel, Zinkernagel, Zinkernagel   +63 more
core   +1 more source

Long-term effects of intermittent IL-2 in HIV infection: extended follow-up of the INSIGHT STALWART Study [PDF]

, 2012
BACKGROUND The Study of Aldesleukin with and without Antiretroviral Therapy (STALWART) was designed to evaluate whether intermittent IL-2 alone or with peri-cycle ART increased CD4+ cell counts (and so delayed initiation of ART) in HIV infected ...
Babiker, Abdel, Fisher, Martin, for the STALWART Study Group,, Fox, Lawrence, Gey, Daniela, Lopardo, Gustavo, Markowitz, Norman, Tavel, Jorge, Wentworth, Deborah   +8 more
core   +5 more sources

Interleukin-10 inhibits the production of inflammatory cytokines by antigen-stimulated mononuclear cells from asthmatic patients

Allergology International, 2000
Bronchial asthma, characterized by chronic airway inflammation, involves many inflammatory cytokines. Interleukin (IL)-10 is a potent inhibitor of cytokine synthesis.
Toshiya Takahashi, Ken-ichi Maeda, Yoichi Nakamura, Yoshio Okano, Ning Ge, Saburo Sone   +5 more
doaj   +1 more source

Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center

Frontiers in Pediatrics, 2022
PurposeHepatoblastoma (HB) tumor rupture is currently considered as a high-risk factor in some risk stratification systems. This study aimed to investigate the value of HB tumor rupture in predicting the poor prognosis.MethodsThe clinical data from ...
Yu-Tong Zhang, Yu-Fei Zhao, Dian-Fei Yang, Jian Chang   +3 more
doaj   +1 more source

Treatment of refractory chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation with low-dose interleukin-2

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015
Refractory chronic graft-versus-host disease (cGVHD) is the complication of allogeneic hematopoietic stem cell transplantation (HCT) that signi ficantly impacts quality of life, may be associated with morbidity and mortality and has limited treatment ...
I. S. Moiseev, E. A. Burmina, Y. A. Tarakanova, Y. R. Zalyalov, A. G. Smirnova, O. V. Pirogova, S. N. Bondarenko, B. V. Afanasyev   +7 more
doaj   +1 more source