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Current Protocols in Immunology, 2007
AbstractThis unit describes three procedures for measurement of interleukin‐21 (IL‐21). The first employs the use of an antibody sandwich ELISA. An alternative procedure measures proliferative responses of T cells to a combination of IL‐21 and IL‐15 using CFSE.
Warren J. Leonard +2 more
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AbstractThis unit describes three procedures for measurement of interleukin‐21 (IL‐21). The first employs the use of an antibody sandwich ELISA. An alternative procedure measures proliferative responses of T cells to a combination of IL‐21 and IL‐15 using CFSE.
Warren J. Leonard +2 more
openaire +3 more sources
Optimization of interleukin-21 immunotherapeutic strategies [PDF]
Journal of Theoretical Biology, 2007 The recently discovered interleukin-21 (IL-21) shows strong tumor attenuation in preclinical studies, and is considered a promising cancer immunotherapy agent. Yet, to exploit its potential, therapeutic strategies must be designed to achieve adequate balance between several conflicting aspects.
Moran Elishmereni +2 more
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Immune Modulation with Interleukin‐21
Annals of the New York Academy of Sciences, 2009Interleukin 21 (IL‐21) is produced by activated CD4+ T cells. The IL‐21R shares the common receptor gamma‐chain with IL‐2, IL‐4, IL‐7, IL‐9, and IL‐15, is widely expressed on immune cells, and mediates a variety of effects on the immune system. IL‐21 enhances the proliferation, antigen‐induced activation, clonal expansion, IFN‐γ production, and ...
William E. Carson, Neela Bhave
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Role of Interleukin-21 in Inflammation and Allergy
Inflammation & Allergy-Drug Targets, 2007Interleukin-21 (IL-21) is a newly described cytokine, produced by activated CD4+ T cells. Since the discovery in 2000, IL-21 has been the object of intensive research because of its homology to IL-2, IL-4 and IL-15, and its ability to modulate both innate and adaptive immune responses.
Fina D. +3 more
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Interleukin‐21 in chronic inflammatory diseases
BioFactors, 2013Interleukin‐21 (IL‐21), a cytokine produced by various subsets of activated CD4+ T cells, regulates multiple innate and adaptive immune responses. Indeed, IL‐21 controls the proliferation and function of CD4+ and CD8+ T lymphocytes, drives the differentiation of B cells into memory cells and Ig‐secreting plasma cells, enhances the activity of natural ...
Sarra, M +2 more
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Interleukin-21 in Immune and Allergic Diseases
Inflammation & Allergy-Drug Targets, 2012Interleukin-21 (IL-21), a cytokine produced by various subsets of activated CD4+ T cells, plays a major role in the control of innate and adaptive immune responses. IL-21 biological activity is mediated by binding of the cytokine to a heterodimeric receptor, composed of a specific subunit, termed IL-21 receptor (IL-21R), and the common γ-chain, that is
Sarra, M +3 more
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Targeting interleukin-21 in inflammatory diseases
Expert Opinion on Therapeutic Targets, 2011IL-21, a new member of the type 1 cytokine superfamily, is produced by various subsets of CD4(+) T cells and binds to a composite receptor that consists of a specific receptor, termed IL-21 receptor and the common γ-chain subunit. Initially considered to be a critical regulator of T and B cell function, IL-21 is now known to regulate the activity of ...
Sarra, M +3 more
openaire +5 more sources