Results 301 to 310 of about 528,114 (310)

Interleukin-21 Inhibits HBV Replication in vitro

Antiviral Therapy, 2014
Background Cytokines are crucial factors in the non-cytolytic antiviral process to inhibit HBV gene expression and replication. Interleukin (IL)-21 has been suggested to play an important role in HBV infection, but it remains unknown whether IL-21 can inhibit HBV replication or how it inhibits HBV replication. Methods In this study, we investigated the
Hai-Jun, Li, Fu-Biao, Kang, Bao-Sheng, Li, Xin-Ying, Yang, Yin-Ge, Zhang, Dian-Xing, Sun   +5 more
openaire   +2 more sources

Expression, purification and characterization of recombinant interleukin-21

Journal of Immunological Methods, 2010
Interleukin-21 (IL-21) is a key regulator of the immune system. However, studies of this cytokine have so far been hampered by the limited availability of recombinant protein preparations. Here we describe a method based on refolding of inclusion bodies expressed in E. coli by rapid dilution.
Carol M Y, Lee, Helen, McGuire, Antony, Basten, Cecile, King, Daniel, Christ   +4 more
openaire   +2 more sources

Interleukin-21 inhibits dendritic cell activation and maturation

Blood, 2003
AbstractInterleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common γ chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendritic cells (DCs), we analyzed effects of IL-21 ...
Brandt, Katja, Bulfone-Paus, Silvia, Foster, Donald C., Rückert, René   +3 more
openaire   +3 more sources

Interleukin-21 in T cell-mediated diseases.

Discovery medicine, 2009
Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin, pancreas, and joints.
MONTELEONE, GIOVANNI, Sarra, M, PALLONE, FRANCESCO   +2 more
openaire   +2 more sources

Circulating HIV-Specific Interleukin-21

2016
OA ...
Schultz, Bruce T., Teigler, Jeffrey E., Pissani, Franco, Oster, Alexander F., Kranias, Gregory, Alter, Galit, Marovich, Mary, Eller, Michael A., Dittmer, Ulf, Robb, Merlin L., Kim, Jerome H., Michael, Nelson L., Bolton, Diane, Streeck, Hendrik   +13 more
openaire   +1 more source

Interleukin-21 Deficiency

2020
Robert P. Nelson, Javier Chinen
openaire   +1 more source

Interleukin 21

2016
Rosanne Spolski, Warren J. Leonard
openaire   +1 more source

Interleukin-21 signaling

Reactome - a curated knowledgebase of biological pathways, 2017
openaire   +1 more source

Immunobiology of Interleukin-21

2014
Cecile King, Helen McGuire
openaire   +1 more source

Immunomodulation of Neoplasia by Interleukin 21

2015
Jeffrey L. Rossio, Frances W. Ruscetti
openaire   +1 more source