Results 61 to 70 of about 528,114 (310)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients

Cells, 2019
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). T helper (Th) 17 lymphocytes play a role in the pathogenesis of MS.
Alessia Capone, Manuela Bianco, Gabriella Ruocco, Marco De Bardi, Luca Battistini, Serena Ruggieri, Claudio Gasperini, Diego Centonze, Claudio Sette, Elisabetta Volpe   +9 more
doaj   +1 more source

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

IL‐21 regulates macrophage activation in human monocytic THP‐1‐derived macrophages

Rheumatology & Autoimmunity, 2021
Background: Interleukin‐21 (IL‐21) has a regulatory effect on various immune cells. Its effect on macrophage function remains unclear. Aims: This study aimed to investigate the effect of IL‐21 on the macrophages‐mediated inflammatory response and explore
Leilei Jian, Changhong Li, Lin Sun, Zhenzhen Ma, Xinyu Wang, Ruohan Yu, Xiangyuan Liu, Jinxia Zhao   +7 more
doaj   +1 more source

The role of interleukin-21 in HIV infection [PDF]

Cytokine & Growth Factor Reviews, 2012
Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γ(c)). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the ...
Suresh, Pallikkuth, Anita, Parmigiani, Savita, Pahwa   +2 more
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells. [PDF]

PLoS ONE, 2015
Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival.
Loris De Cecco, Matteo Capaia, Simona Zupo, Giovanna Cutrona, Serena Matis, Antonella Brizzolara, Anna Maria Orengo, Michela Croce, Edoardo Marchesi, Manlio Ferrarini, Silvana Canevari, Silvano Ferrini   +11 more
doaj   +1 more source

Autoimmune gastrointestinal complications in patients with Systemic Lupus Erythematosus: case series and literature review [PDF]

, 2016
The association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports.
Agmon-Levin N, Ahmed QM, Akram S, Arnett FC, Bessone F, Breuer GS, Byun JY, Cabrera GE, Carmona-Fernandes D, Carone FA, Chebli JM, Chong WP, Chowdhary VR, Cortese AF, Cowling DC, Criş cov GI, Culp KS, D A Isenberg, De Jager PL, Denham JM, Dreiling DA, Dubois EL, Ebert EC, Efe C, Efe C, Einarsdottir E, Essaadouni L, Fernández Rodríguez AM, Ferreiros-Vidal I, Fina D, Floreani A, Freeman HJ, Gershwin ME, Gibson T, Grimbacher B, Gupta D, Hallegua DS, Hamed I, Han S, Harada K, Hennes EM, Her M, Homberg JC, Irving KS, Isenberg DA, Janssens P, Joske RA, Ju JH, Kapila N, Katsanos KH, Katsanos KH, Laing TJ, Lee C-K, Leggett BA, Leonard WJ, Levy C, Lohse AW, Ludvigsson JF, Mackay IR, Makol A, Matsumoto T, Medina F, Michalopoulos G, Miller MH, Miyazaki T, Muratori P, Nakou M, Nesher G, Netto AP, Nitzan O, Park SW, Pascual-Ramos V, Pisetsky DS, Pollak VE, Reifenstein EC, Rensch MJ, Reynolds JC, Rodriguez EA, Runyon BA, Rustgi AK, S Custódio Alves, S Fasano, Seelig R, Serrano López MC, Shapeero LG, Shizuma T, Shizuma T, Sparberg M, Steffan W, Sultan SM, Sánchez-Guerrero J, Takahashi A, Taourel P, Thomas JR, Tian X-P, van Hoek B, Vergani D, Vitali C, Yamashita H, Zheng R-H, Zizic TM, Zizic TM   +101 more
core   +1 more source

Interleukin-21-Mediated TLR4 Activation in Celiac Disease [PDF]

Digestive Diseases and Sciences, 2013
Dear Editor, We read with great interest the recent contribution by Eiro et al. [1]. They reported that celiac disease (CD) patients with high levels of toll-like receptor 4 (TLR4) showed high levels of interleukins (IL-1, IL-6, IL-8, and IL-17) as well as transcription factors. However, unfortunately, they did not analyze the expression of IL-21.
Se Jin, Park, Jae Il, Shin
openaire   +3 more sources