Results 61 to 70 of about 61,069,248 (252)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Abnormal expansion of peripheral helper T cells in primary immune thrombocytopenia

Platelets
Peripheral helper T (Tph) cells, a distinct T-cell subset defined as CD4+PD-1hiCXCR5− phenotypically, are increasingly recognized as key drivers of antibody-mediated autoimmunity; however, their role in primary immune thrombocytopenia (ITP) remains ...
Qian Liu, Tianshu Yu, Yimin Zhou, Xiran Hou, Le Jiang, Jiaqi Liu, Jiayi Zhu, Yajing Zhao, Zhenyu Yan, Xinguang Liu   +9 more
doaj   +1 more source

IL‐21 regulates macrophage activation in human monocytic THP‐1‐derived macrophages

Rheumatology & Autoimmunity, 2021
Background: Interleukin‐21 (IL‐21) has a regulatory effect on various immune cells. Its effect on macrophage function remains unclear. Aims: This study aimed to investigate the effect of IL‐21 on the macrophages‐mediated inflammatory response and explore
Leilei Jian, Changhong Li, Lin Sun, Zhenzhen Ma, Xinyu Wang, Ruohan Yu, Xiangyuan Liu, Jinxia Zhao   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells. [PDF]

PLoS ONE, 2015
Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival.
Loris De Cecco, Matteo Capaia, Simona Zupo, Giovanna Cutrona, Serena Matis, Antonella Brizzolara, Anna Maria Orengo, Michela Croce, Edoardo Marchesi, Manlio Ferrarini, Silvana Canevari, Silvano Ferrini   +11 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Frontiers in Immunology, 2019
Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines.
Yi Wang, Hua Jiang, Hong Luo, Yansha Sun, Bizhi Shi, Ruixin Sun, Zonghai Li, Zonghai Li   +7 more
doaj   +1 more source

Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway

, 2002
Granulomatous Diseases Review Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production ...
Kumararatne, D.S., Baretto, Richard, De Heer, E., J.F. EMILE, Ottenhoff, THM, De Heer, E, Edgar, JD, Binch, J., Ottenhoff, T.H., Casanova, J.L., Lammas, David, Lammas, D.A., Edgar, J, Kumararatne, DS, Panchalingam, S, Novelli, V., E. DE HEER, Drysdale, P, Binch, J, Ottenhoff, TH, Panchalingam, S., Emile, JF, Drysdale, Pamela, C. MACLENNAN, T. H. M. OTTENHOFF, Ben-smith, Anne, Novelli, V, P. DRYSDALE, MacLennan, Calman, R. BARETTO, Casanova, JL, J. BINCH, Ben-Smith, A., Casanova, J-L, Ben-Smith, A, Drysdale, P., Emile, J.F., D. S. KUMARARATNE, Baretto, R, Baretto, R., S. PANCHALINGAM, J.-L. CASANOVA, MacLennan, C, J. D. EDGAR, A. BEN-SMITH, Kumararatne, Dinakantha, D. A. LAMMAS, MacLennan, C., Lammas, David A, V. NOVELLI   +49 more
core   +1 more source

Prevention of arthritis by interleukin 10-producing B cells [PDF]

, 2003
In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Mauri, C., Mushtaq, N., Marco Londei, Claudia Mauri, Naseem Mushtaq, Gray, D., Londei, M., David Gray   +7 more
core   +1 more source