Results 71 to 80 of about 3,093,388 (334)

Expression of interleukin‐21 receptor, but not interleukin‐21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 2004
AbstractObjectiveTo determine the role and expression of the cytokine/receptor pair interleukin‐21 (IL‐21)/IL‐21 receptor (IL‐21R) in rheumatoid arthritis (RA).MethodsThe expression of IL‐21R and IL‐21 was analyzed by TaqMan real‐time polymerase chain reaction (PCR) and in situ hybridization of synovial biopsy samples from patients with RA and ...
Astrid, Jüngel, Jörg H W, Distler, Mariola, Kurowska-Stolarska, Christian A, Seemayer, Reinhart, Seibl, Adrian, Forster, Beat A, Michel, Renate E, Gay, Frank, Emmrich, Steffen, Gay, Oliver, Distler   +10 more
openaire   +2 more sources

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly. [PDF]

, 2014
The impairment of humoral immune response in elderly humans has been extensively demonstrated. We have reported the increase of memory B cells (IgG+IgD−CD27−, double negative, DN) population in the elderly, in which there is also a typical inflammatory ...
BUFFA, Silvio, BULATI, Matteo, CANDORE, Giuseppina, CARUSO, Calogero, COLONNA ROMANO, Giuseppina, LIO, Domenico, MARTORANA, Adriana   +6 more
core   +1 more source

Expressions of IL-17, IL-21 and IL-23 in the serum of allergic rhinitis patients [PDF]

Journal of Medical Biochemistry, 2011
The present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum.
Huang Xuekun, Yang Qintai, Chen Yulian, Peng Li, Zhang Gehua, Yuan Li   +5 more
doaj  

Raman spectroscopic detection of interleukin-10 and angiotensin converting enzyme

Journal of the European Optical Society-Rapid Publications, 2021
In this report we present a confocal Raman system to identify the unique spectral features of two proteins, Interleukin-10 and Angiotensin Converting Enzyme. Characteristic Raman spectra were successfully acquired and identified for the first time to our
Shuo Zhang, Frederieke A. M. van der Mee, Roel J. Erckens, Carroll A. B. Webers, Tos T. J. M. Berendschot   +4 more
doaj   +1 more source

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases

Frontiers in Immunology, 2022
Interleukins 4 (IL-4) and 21 (IL-21) belong to the common gamma chain cytokine family which are highly involved in the progression of autoimmune diseases.
Chin Wai Hui, Wai Chung Wu, Shui On Leung   +2 more
doaj   +1 more source

Interleukin 21 (IL-21)/microRNA-29 (miR-29) axis is associated with natural resistance to HIV-1 infection

AIDS (London), 2018
Background: Interleukin-21 (IL-21) modulates HIV-1 infection through the elicitation of different antiviral mechanisms, including Th17 lineage commitment and induction of microRNA (miR)-29, a miRNA endowed with anti-HIV activity.
Paula A S Ortega, I. Saulle, V. Mercurio, S. Ibba, E. Lori, C. Fenizia, Michela Masetti, D. Trabattoni, S. Caputo, F. Vichi, F. Mazzotta, M. Clerici, M. Biasin   +12 more
semanticscholar   +1 more source

Interleukin-21 Signaling: Functions in Cancer and Autoimmunity [PDF]

Clinical Cancer Research, 2007
Abstract Interleukin-21 (IL-21) is a cytokine with structural and sequence homology to IL-2 and IL-15, yet possesses several biological properties distinct from these cytokines. IL-21 is produced mainly by activated CD4+ T cells and natural killer T cells and mediates its activity by binding to the IL-21 receptor (IL-21R), consisting of ...
Davis, Ian D., Skak, Kresten, Smyth, Mark J., Kristjansen, Paul E.G., Miller, Dennis M., Sivakumar, Pallavur V.   +5 more
openaire   +4 more sources

Mucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity of gastritis [PDF]

, 2015
Helicobacter pylori (H. pylori) infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells. Different clinical forms of the infection may reflect distinctive patterns of cytokine
Azadegan-Dehkordi, Fatemeh., Bagheri, Nader., Rafieian-Kopaei, Mahmoud., Rahimian, Ghorbanali., shirzad, Hedayatollah., Shirzad, Mahsa., Taghikhani, Afshin., Zamanzad, Behnam.   +7 more
core   +2 more sources

Interleukin 21 Reinvigorates the Antiviral Activity of Hepatitis B Virus (HBV)–Specific CD8+ T Cells in Chronic HBV Infection

Journal of Infectious Diseases, 2018
BACKGROUND Strategies that target functional recovery of exhausted hepatitis B virus (HBV)-specific CD8+ T cells are beneficial for viral control, but the potential for interleukin 21 (IL-21) to rescue CD8+ T-cell function is not well understood ...
Libo Tang, Chengcong Chen, Xueping Gao, Wanyue Zhang, Xin Yan, Yang Zhou, Ling Guo, Xinchun Zheng, Weibin Wang, Fuqiang Yang, Guang-ze Liu, Jian Sun, J. Hou, Yongyin Li   +13 more
semanticscholar   +1 more source