Results 81 to 90 of about 3,093,388 (334)

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity [PDF]

, 2011
The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex.
Alban Ordureau, Banchereau, Bessa, Boone, Cheung, Chu, Conze, David W. Powell, Döffinger, Ea, El Bakkouri, Haas, Han, He, He, Heyninck, Heyninck, Hwang, Inohara, J. Simon C. Arthur, Janet C. Patterson-Kane, Kanayama, Kawagoe, Kirisako, Komander, Kulathu, Ma, Marshak-Rothstein, Nair, Nurieva, Ordureau, Oshima, Pasare, Peng, Philip Cohen, Plenge, Rachel Toth, Rahighi, Ram K.C. Venigalla, Sambit K. Nanda, Sato, Sato, Schmitt, Shim, Sutmuller, Tavares, Thomson, Tokunaga, Vinuesa, Vinuesa, Wagner, Walsh, Wang, Wertz, Windheim, Windheim, Wu, Xia   +57 more
core   +5 more sources

Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children

Pediatric Rheumatology Online Journal, 2017
Background Kawasaki disease (KD) is a febrile childhood vasculitis of unknown etiology. The diagnosis is highly concerning as over a quarter of children who fail to receive timely treatment with intravenous immunoglobulin (IVIG) will develop coronary ...
Rachel Engelberg, Meghan Martin, Brian H. Wrotniak, Mark Daniel Hicar   +3 more
doaj   +1 more source

T-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression.

Journal of Clinical Oncology, 2016
Purpose Peripheral blood-derived antigen-specific cytotoxic T cells (CTLs) provide a readily available source of effector cells that can be administered with minimal toxicity in an outpatient setting.
A. Chapuis, Ilana M. Roberts, John A Thompson, K. Margolin, S. Bhatia, Sylvia M. Lee, H. Sloan, Ivy P. Lai, Erik A. Farrar, F. Wagener, Kendall C. Shibuya, Jianhong Cao, J. Wolchok, P. Greenberg, C. Yee   +14 more
semanticscholar   +1 more source

Transient Expression of Interleukin-21 in the Second Hit of Acute Pancreatitis May Potentiate Immune Paresis in Severe Acute Pancreatitis

Pancreas, 2019
Objectives Interleukin-21 (IL-21) is a cytokine associated with tissue inflammation, autoimmune and infectious diseases. Organ dysfunction and death can occur in patients with acute pancreatitis (AP) in two distinct clinical phases. Initially, a systemic
J. Thomson, E. Nweke, M. Brand, M. Nel, G. Candy, P. Fonteh   +5 more
semanticscholar   +1 more source

Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy. [PDF]

PLoS ONE, 2013
Both physiological and psychological stress cause thymic atrophy via glucocorticoïd (GC)-dependent apoptosis of double-positive (DP) thymocytes. Given the pervasiveness of stress, GC-induced thymic atrophy is arguably the most common type of acquired ...
Moutih Rafei, Maude Dumont-Lagacé, Alexandre Rouette, Claude Perreault   +3 more
doaj   +1 more source

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]

, 2011
Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Albers HM, Barrett JC, Barrett JC, Bergquist A, Bergquist A, Bo X, Burkhard Göke, Chapman R, Chen B, Christian Rust, Daha NA, Fay MP, Festen EA, Gerald Ulrich Denk, Gershwin ME, Gershwin ME, Glas J, Glas J, Henckaerts L, Hinks A, Hirschfield GM, Johannes Stallhofer, Jürgen Glas, Kaplan MM, Karlsen TH, Laurence A, Li Y, Liu Y, Loftus, Loftus EV, Maiti AK, Malek TR, Marquez A, McGuire HM, Peluso I, Rüdiger Paul Laubender, Saarinen S, Sadlack B, Saich R, Saraiva M, Sawalha AH, Sgouroudis E, Stephan Brand, Thomas Pusl, Todd JA, van Heel DA, Weismuller TJ, Yamanouchi J, Yang L, Zheng SG, Zhernakova A, Zhernakova A   +51 more
core   +1 more source

Interleukin 21 treatment in a murine model as a novel potential cytokine immunotherapy for colon cancer.

Advances in Clinical and Experimental Medicine, 2018
BACKGROUND Interleukin 21 (IL-21), which belongs to the common γ-chain (γc) family, is a novel tumor suppressor that has been shown to affect T-cell proliferation, survival and function.
Chen Chen, Xiaoning Liu, Yi Ren
semanticscholar   +1 more source

Modulation of tryptophan/serotonin pathway by probiotic supplementation in human immunodeficiency virus-positive patients: preliminary results of a new study approach [PDF]

, 2017
Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals.
Cavallari, Eugenio Nelson, Ceccarelli, Giancarlo, Corano Scheri, Giuseppe, D'Ettorre, Gabriella, DE GIROLAMO, Gabriella, Giustini, Noemi, Laghi, Luca, Mastrangelo, Andrea, Najafi Fard, Saeid, Pinacchio, Claudia, Schietroma, Ivan, Serafino, Sara, Statzu, Maura, Vullo, Annamaria, Vullo, Vincenzo   +14 more
core   +3 more sources

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Frontiers in Immunology, 2019
Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines.
Yi Wang, Hua Jiang, Hong Luo, Yansha Sun, Bizhi Shi, Ruixin Sun, Zonghai Li, Zonghai Li   +7 more
doaj   +1 more source

IL‐21 regulates macrophage activation in human monocytic THP‐1‐derived macrophages

Rheumatology & Autoimmunity, 2021
Background: Interleukin‐21 (IL‐21) has a regulatory effect on various immune cells. Its effect on macrophage function remains unclear. Aims: This study aimed to investigate the effect of IL‐21 on the macrophages‐mediated inflammatory response and explore
Leilei Jian, Changhong Li, Lin Sun, Zhenzhen Ma, Xinyu Wang, Ruohan Yu, Xiangyuan Liu, Jinxia Zhao   +7 more
doaj   +1 more source