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Biology of interleukin-22

Seminars in Immunopathology, 2010
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and ...
Kerstin, Wolk   +4 more
openaire   +2 more sources

Interleukin-22

American Journal of Respiratory Cell and Molecular Biology, 2004
Abstract Interleukin (IL)-22 is a member of the human type I interferon family, which includes IL-10. IL-22 has the potential to interact with IL-10 because it binds to the IL-10R2c chain with IL-22R1 in its receptor complex. Binding can be blocked by the soluble receptor, IL-22 binding protein (IL-22BP). We hypothesize that IL-22 and
Hayley A. Whittington   +3 more
openaire   +1 more source

Role of interleukin-22 in tuberculosis patients

Journal of Basic and Clinical Physiology and Pharmacology, 2022
Abstract Objectives Disease progression of tuberculosis (TB) depends on the balance between the microorganism’s virulence and the host defense systems (mainly T cell-mediated immune response).
Shruti Gupta   +9 more
openaire   +2 more sources

Temporal expression of interleukin‐22, interleukin‐22 receptor 1 and interleukin‐22‐binding protein during experimental periodontitis in rats

Journal of Periodontal Research, 2017
Background and ObjectiveInterleukin‐22 (IL‐22), mainly produced by CD4+ T‐helper subtypes and innate lymphoid cells at barrier surfaces, is found to involve in several diseases, including diabetes, rheumatoid arthritis, peri‐implantitis and chronic rhinosinusitis with nasal polyps.
S. Pan   +6 more
openaire   +2 more sources

The role of interleukin-22 in pityriasis rosea

Clinical and Experimental Dermatology, 2016
Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR.To measure the serum level of interleukin (IL)-22, a cytokine expressed by T helper (Th)17 ...
S. Al Mokadem   +3 more
openaire   +2 more sources

Interleukin-22/Interleukin-22 binding protein axis and oral contraceptive use in polycystic ovary syndrome

Endocrine, 2023
Polycystic ovary syndrome (PCOS) is associated with alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by immune cells and closely linked to gut immunity, which is tightly controlled by its binding protein (IL-22BP). In this study, we aimed to assess whether IL-22/IL-22BP axis is altered in PCOS at baseline and in response ...
Seren Aksun   +3 more
openaire   +3 more sources

Targeting Interleukin-22 in Psoriasis

Inflammation, 2013
Interleukin-22 (IL-22) is an IL-10 family cytokine that was recently discovered to be released by T helper 17 (Th17) cells, Th22 cells, etc. Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of psoriasis.
openaire   +2 more sources

Interleukin-22 in kidney injury and regeneration

American Journal of Physiology-Renal Physiology, 2015
Interleukins have become well-known regulators of innate and adaptive immunity-related tissue inflammation. Recently, IL-22 has gained a lot of interest for its unique functions in maintaining and regaining epithelial integrity. IL-22 is exclusively secreted by different immune cell subsets, while IL-22 receptors are mainly expressed by epithelial ...
Marc, Weidenbusch   +2 more
openaire   +2 more sources

A RAPID BIOASSAY FOR RECOMBINANT INTERLEUKIN-22

Journal of Immunoassay and Immunochemistry, 2009
Interleukin-22 is a novel cytokine produced mainly in activated T cells. The elaborate biological functions of IL-22 in vivo are still widely unknown. In this report, we describe a rapid, simple, and reproducible in vitro cell-based bioassay for measuring the bioactivity of recombinant interleukin-22 (IL-22) to study the primary function of IL-22 in ...
Fei, Xu   +5 more
openaire   +2 more sources

INTERLEUKIN-22 DETECTED IN PATIENTS WITH ABDOMINAL SEPSIS

Shock, 2010
Interleukin 22 (IL-22) is a TH17-like cytokine known to specifically activate epithelial cells, thereby strengthening immune defense at host/environment interfaces. Animal studies suggest that IL-22 may play a crucial role in clinical sepsis. However, little is known about IL-22 in sepsis patients.
Tobias M, Bingold   +11 more
openaire   +2 more sources

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