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Journal of Periodontal Research, 2017
Background and ObjectiveInterleukin‐22 (IL‐22), mainly produced by CD4+ T‐helper subtypes and innate lymphoid cells at barrier surfaces, is found to involve in several diseases, including diabetes, rheumatoid arthritis, peri‐implantitis and chronic rhinosinusitis with nasal polyps.
S. Pan +6 more
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Background and ObjectiveInterleukin‐22 (IL‐22), mainly produced by CD4+ T‐helper subtypes and innate lymphoid cells at barrier surfaces, is found to involve in several diseases, including diabetes, rheumatoid arthritis, peri‐implantitis and chronic rhinosinusitis with nasal polyps.
S. Pan +6 more
openaire +2 more sources
Endocrine, 2023
Polycystic ovary syndrome (PCOS) is associated with alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by immune cells and closely linked to gut immunity, which is tightly controlled by its binding protein (IL-22BP). In this study, we aimed to assess whether IL-22/IL-22BP axis is altered in PCOS at baseline and in response ...
Seren Aksun +3 more
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Polycystic ovary syndrome (PCOS) is associated with alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by immune cells and closely linked to gut immunity, which is tightly controlled by its binding protein (IL-22BP). In this study, we aimed to assess whether IL-22/IL-22BP axis is altered in PCOS at baseline and in response ...
Seren Aksun +3 more
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The role of interleukin-22 in pityriasis rosea
Clinical and Experimental Dermatology, 2016Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR.To measure the serum level of interleukin (IL)-22, a cytokine expressed by T helper (Th)17 ...
S. Al Mokadem +3 more
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Targeting Interleukin-22 in Psoriasis
Inflammation, 2013Interleukin-22 (IL-22) is an IL-10 family cytokine that was recently discovered to be released by T helper 17 (Th17) cells, Th22 cells, etc. Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of psoriasis.
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A RAPID BIOASSAY FOR RECOMBINANT INTERLEUKIN-22
Journal of Immunoassay and Immunochemistry, 2009Interleukin-22 is a novel cytokine produced mainly in activated T cells. The elaborate biological functions of IL-22 in vivo are still widely unknown. In this report, we describe a rapid, simple, and reproducible in vitro cell-based bioassay for measuring the bioactivity of recombinant interleukin-22 (IL-22) to study the primary function of IL-22 in ...
Fei, Xu +5 more
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Interleukin-22 in kidney injury and regeneration
American Journal of Physiology-Renal Physiology, 2015Interleukins have become well-known regulators of innate and adaptive immunity-related tissue inflammation. Recently, IL-22 has gained a lot of interest for its unique functions in maintaining and regaining epithelial integrity. IL-22 is exclusively secreted by different immune cell subsets, while IL-22 receptors are mainly expressed by epithelial ...
Marc, Weidenbusch +2 more
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Interleukin‐22 and Its Crystal Structure
2006Interleukin-22 (IL-22) is a cytokine that regulates the production of acute phase proteins of the immunological response. On binding to its cognate receptor (IL-22R1), which is associated to the interleukin-10 receptor 2 (IL-10R2), IL-22 promotes activation of signal transducer and activator of transcription (STAT) pathway and several other cellular ...
Ronaldo Alves Pinto, Nagem +4 more
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INTERLEUKIN-22 DETECTED IN PATIENTS WITH ABDOMINAL SEPSIS
Shock, 2010Interleukin 22 (IL-22) is a TH17-like cytokine known to specifically activate epithelial cells, thereby strengthening immune defense at host/environment interfaces. Animal studies suggest that IL-22 may play a crucial role in clinical sepsis. However, little is known about IL-22 in sepsis patients.
Tobias M, Bingold +11 more
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Interleukin-22 is a negative regulator of the allergic response
Cytokine, 2010A proinflammatory role of T helper (Th)17 cells, producing IL-22 and IL-17A, has been favored although there is evidence for negative immune regulation by IL-17A. Here we show that IL-22 was produced during an allergic response in lungs of mice, immunized and challenged with ovalbumin (OVA), and that IL-22 neutralization further augmented the ...
Bruno, Schnyder +2 more
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Role of Interleukin-22 in chronic liver injury
Cytokine, 2017Liver fibrosis is the result of an exacerbated wound-healing response associated with chronic liver injury. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and frequently requires liver transplantation. The host immune response has an important role driving fibrosis deposition by activating hepatic stellate cells ...
Rodrigo F, Carmo +2 more
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