Results 111 to 120 of about 73,008,320 (286)

Immunoexpression of Interleukin-22 and Interleukin-23 in Oral and Cutaneous Lichen Planus Lesions: A Preliminary Study

Mediators of Inflammation, 2013
Interleukin- (IL-) 22 is the signature cytokine of T-helper (Th) 22 cells, and IL-23 is required for IL-22 production. The objective of this study was to examine the immunoexpression of IL-22 and IL-23 in archival paraffin-embedded biopsy specimens from ...
Jun Chen, Jinqiu Feng, Xiangdong Chen, Hui Xu, Zengtong Zhou, Xuemin Shen, Zhexuan Bao, Wei Liu, Zhengyu Shen   +8 more
doaj   +1 more source

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22.

PLoS Biology, 2019
Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains intestinal homeostasis and promotes wound healing and tissue regeneration, which can support the growth of colorectal tumours.
Yu Chen, Maud Vandereyken, Ian P Newton, Ignacio Moraga, Inke S Näthke, Mahima Swamy   +5 more
doaj   +1 more source

Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy

Arthritis Care &Research, EarlyView.
Objective We aimed to determine whether the short‐term response to biologics in biologic‐naive psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods Patients with PsA who started on biologic therapy from the year 2000 to 2025 were included for analysis.
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

IL-23-producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response.

, 2020
Cytokines maintain intestinal health, but precise intercellular communication networks remain poorly understood. Macrophages are immune sentinels of the intestinal tissue and are critical for gut homeostasis.
Louise Chappell-Maor (2559871), Eyal David (669456), Eran Elinav (192785), Venizelos Papayannopoulos (193171), Masha Kolesnikov (8272896), Caterina Curato (768889), Steffen Jung (192792), Marianna Ioannou (5211254), Alon Harmelin (43332), Biana Bernshtein (6634181), Qian Wang (32718), Christoph A Thaiss (8272890), Mor Gross-Vered (8272893), Paresh Thakker (2433097)   +13 more
core  

Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains.

, 2008
Interleukin-22 (IL-22) is a class 2 cytokine whose primary structure is similar to that of interleukin 10 (IL-10) and interferon-gamma (IFN-gamma). IL-22 induction during acute phase immune response indicates its involvement in mechanisms of inflammation.
Nascimento, Alessandro S, José Ribamar Ferreira, Hannes Fischer, Igor Polikarpov, Mario de Oliveira Neto, OLIVEIRA NETO, Mario de, Alessandro S. Nascimento, Renauld, Jean-Christophe, Didier Colau, Ferreira, José Ribamar, FERREIRA JR., Jose Ribamar, Jean-Christophe Renauld, Laure Dumoutier, Craievich, Aldo F, NASCIMENTO, Alessandro S., de Oliveira Neto, Mario, Polikarpov, Igor, Aldo F. Craievich, Colau, Didier, Dumoutier, Laure, CRAIEVICH, Aldo F., Fischer, Hannes   +21 more
core   +1 more source

Interleukin-22 signaling in the regulation of intestinal health and disease

Frontiers in Cell and Developmental Biology, 2016
Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of ...
Olivia B. Parks, Derek A. Pociask, Derek A. Pociask, Zerina eHodzic, Jay K. Kolls, Jay K. Kolls, Misty eGood, Misty eGood   +7 more
doaj   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Prevention of arthritis by interleukin 10-producing B cells [PDF]

, 2003
In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Mauri, C., Mushtaq, N., Marco Londei, Claudia Mauri, Naseem Mushtaq, Gray, D., Londei, M., David Gray   +7 more
core   +1 more source

Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice

Mediators of Inflammation, 2017
Background. Interleukin- (IL-) 22 is considered a proinflammatory cytokine. Recent evidence has demonstrated that it plays a role in cardiovascular diseases. In the recent study, we investigate whether IL-22 is involved in cardiac hypertrophy.
Jing Ye, Ling Liu, Qingwei Ji, Ying Huang, Ying Shi, Lei Shi, Jianfang Liu, Menglong Wang, Yao Xu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan   +12 more
doaj   +1 more source