Results 91 to 100 of about 73,008,320 (286)

Toll-like receptor 2 coordinates induction of IL-22 in lung macrophages following organic dust-induced inflammation

Frontiers in Physiology
IntroductionOrganic dust exposures, particularly in occupational settings, induce airway inflammation and contribute to the development and progression of chronic lung disease and impaired tissue regeneration.
Emmanuel O. Oyewole, Emmanuel O. Oyewole, Emmanuel O. Oyewole, Pinaki Mondal, Kaylee Jones, Kaylee Jones, Kaylee Jones, Casey McDermott, Casey McDermott, Casey McDermott, Tori Cunningham, Logan S. Dean, Logan S. Dean, Logan S. Dean, Logan S. Dean, Melea Barahona, Melea Barahona, Alissa N. Threatt, Alissa N. Threatt, Maëlis J. Wahl, Jill A. Poole, Tara M. Nordgren, Tara M. Nordgren, Tara M. Nordgren, Tara M. Nordgren   +24 more
doaj   +1 more source

IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease.

PLoS ONE, 2011
Interleukin (IL)-22 is an effector cytokine, which acts primarily on epithelial cells in the skin, gut, liver and lung. Both pro- and anti-inflammatory properties have been reported for IL-22 depending on the tissue and disease model.
Christian Taube, Christine Tertilt, Gabor Gyülveszi, Nina Dehzad, Katharina Kreymborg, Kristin Schneeweiss, Erich Michel, Sebastian Reuter, Jean-Christophe Renauld, Danielle Arnold-Schild, Hansjörg Schild, Roland Buhl, Burkhard Becher   +12 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Role of Interleukin-22 in liver diseases [PDF]

, 2020
Introduction Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family.
Fan-Rong Wu, Chun-Xiao Pan, Jin-Fang Ge, Jie Tang, Xiao-Yu Wang, • Fei-Hu Chen   +5 more
core  

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Interleukin-22 and interleukin-22 binding protein signaling axis influences intubation status in trauma [PDF]

Background: Interleukin-22 is a cytokine involved in mucosal immunity, whereas interleukin-22 binding protein is a soluble receptor that can potently block interleukin-22.
Shenk, Megan, Smith, Alison, Pociask, Derek, Kolls, Jay K., Anderson, Augustus E., Broome, Jacob, Albuck, Aaron L., Noguera, Valeria, Tatum, Danielle, Duchesne, Juan, Bojanowski, Christine M., Covey, Wid, Jackson-Weaver, Olan, Taghavi, Sharven   +13 more
core   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Cell Reports, 2017
Summary: Gut-derived microbial antigens trigger the innate immune system during acute liver injury. During recovery, regulatory immunity plays a role in suppressing inflammation; however, the precise mechanism underlying this process remains obscure ...
Nobuhiro Nakamoto, Takeru Amiya, Ryo Aoki, Nobuhito Taniki, Yuzo Koda, Kentaro Miyamoto, Toshiaki Teratani, Takahiro Suzuki, Sayako Chiba, Po-Sung Chu, Atsushi Hayashi, Akihiro Yamaguchi, Shunsuke Shiba, Rei Miyake, Tadashi Katayama, Wataru Suda, Yohei Mikami, Nobuhiko Kamada, Hirotoshi Ebinuma, Hidetsugu Saito, Masahira Hattori, Takanori Kanai   +21 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Role of Interleukin-18 in vascular injury: a new pharmacological target for the prevention of restenosis [PDF]

, 2006
Background: Studies in humans as well as in animal models suggest that interleukin-18 (IL-18) plays a crucial role in vascular pathologies. IL-18 is a strong predictor of cardiovascular death in angina and is involved in atherotic plaque destabilization.
Grassia, Gianluca
core   +1 more source