Results 251 to 260 of about 527,379 (343)

Combination of mechanical debridement and interleukin 12 or interleukin 23 therapy for refractory facial pyoderma gangrenosum with NOD2 mutation. [PDF]

JAAD Case Rep
Vague M, Shea M, Thacker S, Onoday H, Ortega Loayza AG.   +4 more
europepmc   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Anti-interleukin-23 treatment linked to improved <i>Clostridioides difficile</i> infection survival. [PDF]

Gut Microbes
Madden GR, Preissner R, Preissner S, Petri WA.   +3 more
europepmc   +1 more source

Additional file 2: of Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23

, 2016
David T. Barkan, Xiaoli Cheng, Herodion Celino, Tran Tran, Ashok Bhandari, Charles S. Craik, Andrej Săli, Mark L. Smythe   +7 more
openalex   +1 more source

Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23 [PDF]

, 2016

core   +1 more source

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

A case of psoriasis and atopic dermatitis-like rash induced by interleukin-17 and interleukin-23 inhibitors successfully controlled with upadacitinib. [PDF]

JAAD Case Rep
Okazaki T, Takahashi T, Sugiura R, Shimada-Omori R, Asano Y.   +4 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Implications for a role of interleukin-23 in the pathogenesis of chronic gastritis and of peptic ulcer disease

, 2008
Vassilios Koussoulas, Spyridon Vassiliou, Evangelos J. Giamarellos‐Bourboulis, Georgios Tassias, Antigone Kotsaki, C. Barbatzas, Michalis Tzivras   +6 more
openalex   +2 more sources

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source