Results 251 to 260 of about 517,111 (322)

CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation. [PDF]

Nature
Ahmed A, Joseph AM, Zhou J, Horn V, Uddin J, Lyu M, Goc J, JRI Live Cell Bank, Sockolow RE, Wing JB, Vivier E, Sakaguchi S, Sonnenberg GF.   +12 more
europepmc   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Additional file 2: of Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23

, 2016
David T. Barkan, Xiaoli Cheng, Herodion Celino, Tran Tran, Ashok Bhandari, Charles S. Craik, Andrej Săli, Mark L. Smythe   +7 more
openalex   +1 more source

Induction of systemic immunity by expression of interleukin‐23 in murine colon carcinoma cells [PDF]

, 2003
Yanqing Wang, Shin‐ichi Ugai, Osamu Shimozato, Ling Yu, Kiyoko Kawamura, Hiroshi Yamamoto, Taketo Yamaguchi, Hiromitsu Saisho, Masatoshi Tagawa   +8 more
openalex   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

The role of interleukin-17 and interleukin-23 inhibitors in the development, progression, and recurrence of cancer: A systematic review. [PDF]

JAAD Int
Vangilbergen M, Stockman A, Van De Velde A, Garmyn M, Punie K, Hillary T.   +5 more
europepmc   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

Activation of the interleukin-23/Th17 axis in major depression: a systematic review and meta-analysis. [PDF]

Eur Arch Psychiatry Clin Neurosci
Moulton CD, Malys M, Hopkins CWP, Rokakis AS, Young AH, Powell N.   +5 more
europepmc   +1 more source

Implications for a role of interleukin-23 in the pathogenesis of chronic gastritis and of peptic ulcer disease

, 2008
Vassilios Koussoulas, Spyridon Vassiliou, Evangelos J. Giamarellos‐Bourboulis, Georgios Tassias, Antigone Kotsaki, C. Barbatzas, Michalis Tzivras   +6 more
openalex   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source