Results 61 to 70 of about 517,111 (322)

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo, Ciccia, Francesco, Cypers, Heleen, Di Benedetto, Paola, Elewaut, Dirk, Fasano, Alessio, Gabrielli, Armando, Guggino, Giuliana, Luchetti, Michele Maria, Milling, Simon, Rizzo, Aroldo, Saieva, Laura, Stampone, Tommaso, Triolo, Giovanni   +13 more
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa- pilot study

Italian Journal of Pediatrics, 2019
Background Vitamin D plays an important role in inflammatory responses after antigen exposure. Interleukin-23 (Il-23) promotes Il-17-dependent inflammation during Pseudomonas aeruginosa (P. aeruginosa) pulmonary infection. We aimed to compare the ability
M. Olszowiec-Chlebna, A. Koniarek-Maniecka, A. Brzozowska, A. Błauż, B. Rychlik, I. Stelmach   +5 more
doaj   +1 more source

Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma [PDF]

, 2015
The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the
Ganjalikhani Hakemi, Mazdak., Ghasemi, Ramin., Khan Ahmad, Hossein., Meshkat, Rezvan., Mosayebian, Ali., Samadi, Morteza.   +5 more
core   +1 more source

Interleukin 23-Helper T Cell 17 Axis as a Treatment Target for Pityriasis Rubra Pilaris. [PDF]

, 2017
Treatment of pityriasis rubra pilaris (PRP) is solely based on its resemblance to psoriasis rather than any knowledge of its pathomechanism. Insight into pathogenic mediators of inflammation is essential for targeted and valid treatment options that ...
Conrad, C., Demaria, O., Feldmeyer, L., Gilliet, M., Hohl, D., Laffitte, E., Mennella, A., Mylonas, A., Yawalkar, N.   +8 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Evaluation of Interleukin-21, 23 and 27 mRNA Expression and Protein Level in Liver Transplant Patients

Iranian Journal of Allergy, Asthma and Immunology, 2018
Cytokines have prominent roles in activating of different T cells and shifting the immune response, in this study the role of three cytokines (IL-21, IL-23 and IL-27) is investigated in the liver transplant rejection.
Afsoon Afshari, Ramin Yaghobi, Negar Azarpira, Bita Gerami Zadeh, Seyed Ali Malek Hosseini, Mojtaba Darbouy, Mohammad Hossein Karimi   +6 more
doaj   +1 more source

Interleukin 23 receptor: Expression and regulation in immune cells [PDF]

, 2023
Ikram Mezghiche, Hanane Yahia‐Cherbal, Lars Rogge, Elisabetta Bianchi   +3 more
openalex   +1 more source

Association of Interleukin 23 Receptor Gene with Sarcoidosis [PDF]

Disease Markers, 2011
Interleukin 23 receptor (IL23R) gene has been reported as a genetic factor strongly associated with inflammatory bowel disease, psoriasis, and ankylosing spondylitis. We investigated the association betweenIL23Rgene single nucleotide polymorphisms (SNPs) and susceptibility to sarcoidosis, including the clinical manifestation of uveitis.Ninety-one ...
Hyun Soo Kim, Dongseok Choi, Lyndell L. Lim, Gopal Allada, Justine R. Smith, Carrie R. Austin, Trudy M. Doyle, Kelley A. Goodwin, James T. Rosenbaum, Tammy M. Martin   +9 more
openaire   +3 more sources

Interleukin-23 receptor gene polymorphisms in osteoporosis

The European Research Journal, 2023
Objectives: Osteoporosis (OP) is a usual disease with a possible genetic predisposition. IL-23 plays a role in physiological bone remodeling and regulates the activity of cells of the bone either directly or indirectly on bone-resorbing osteoclasts as well as on bone-forming osteoblasts.
Firdevs ULUTAŞ, Ozan ÇETİN, Veli ÇOBANKARA   +2 more
openaire   +3 more sources