Results 81 to 90 of about 60,158,519 (252)

The inflammatory cytokine interleukin-23 is elevated in lung cancer, particularly small cell type

, 2016
Aim of the study: Interleukin (IL)-17 and IL-23 play roles in inflammation and autoimmunity. The function of the IL-17/IL-23 pathway has not been completely evaluated in cancer patients.
Tuba Muftuoglu, Caner Cam, Cihan Top, Alpaslan Ozgun, Serkan Celik, Levent Emirzeoglu, Oguz Bigi, Tolga Tuncel, Bulent Karagoz   +8 more
core   +1 more source

cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]

, 2000
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Baeuerle, Patrick A., Kaspers, Bernd, Kirsten Schneider, Schneider, Kirsten, Baeuerle, Daniela, Daniela Baeuerle, Kirsten C. Weining, Puehler, Florian, Elvers, Sandra, Weining, Kirsten C., Florian Puehler, Sandra Elvers, Bernd Kaspers   +15 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Therapeutic Mode of Action of Methotrexate

Central Asian Journal of Medical Sciences, 2016
Objectives: Methotrexate (MTX) has been used in clinical practice for over a half-century and its action mechanism is believed to rely on the direct inhibition of DNA synthesis leading to suppression of cell proliferation.
Dashlkhumbe Byamba, Do-Young Kim, Chimidtseren Soodoi, Enkhtur Yadamsuren, Ariunaa Munkhbayar, Nandintsetseg Batbayar, Dashkhajidmaa Dashdondov, Oyuntsatsral Batsaikhan, Batbaatar Gunchin, Min-Geol Lee   +9 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Mathematical modeling of interleukin-27 induction of anti-tumor T cells response. [PDF]

, 2014
Interleukin-12 is a pro-inflammatory cytokine which promotes Th1 and cytotoxic T lymphocyte activities, such as Interferon-[Formula: see text] secretion. For this reason Interleukin-12 could be a powerful therapeutic agent for cancer treatment.
Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman, Kang-Ling Liao, Avner Friedman, Xue-Feng Bai (333686), Bai Xue-Feng, Liao Kang-Ling, Xue-Feng Bai, Friedman Avner, Kang-Ling Liao (535938), Avner Friedman (54903)   +9 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Ustekinumab in treatment of Crohn’s disease: design, development, and potential place in therapy

Drug Design, Development and Therapy, 2016
Parakkal Deepak, Edward V Loftus Jr Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA Abstract: Crohn’s disease is characterized by a dysregulation of both innate and adaptive immunity responses ...
Deepak P, Loftus EV Jr
doaj  

Survival of Interleukin-17 and Interleukin-23 Inhibitors in Patients Previously Treated With a Tumor Necrosis Factor Inhibitor: Analysis of the Spanish Biobadaderm Registry

Actas Dermo-Sifiliográficas
Interleukin 12/23 inhibitors (IL12/23i) and interleukin 17 and 23 inhibitors (IL17i and IL23i) represent the drug classes with the most favorable expectations for therapeutic response.
R. Rivera-Díaz, A. Quesada, A. Sahuquillo-Torralba, E. Daudén, J.M. Carrascosa, I. Belinchón, F.J. Gomez Garcia, E. Herrera Acosta, D.P. Ruiz Genao, O. Baniandrés Rodriguez, M. Ferrán Farres, P. de la Cueva Dobao, L.R. Fernández-Freire, A. Mateu Puchades, J. Riera-Monroig, J.C. Ruiz Carrascosa, M. Ara Martín, M. Abalde Pintos, M. Roncero Riesco, J.L. Lopez-Estebaranz, C. García-Donoso, I. García-Doval, M. Angel Descalzo   +22 more
doaj   +1 more source

Interleukin-10/Interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history

, 2009
Interleukin-10/Interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family ...
M Kusel (10012535), PG Holt (14457411), A Bosco (13307889), K McKenna (9886307), G Zhang (7349387), PD Sly (14453628), J Rowe (9877307), N De Klerk (13369254)   +7 more
core