Results 101 to 110 of about 2,862,477 (306)

Therapeutic Mode of Action of Methotrexate

Central Asian Journal of Medical Sciences, 2016
Objectives: Methotrexate (MTX) has been used in clinical practice for over a half-century and its action mechanism is believed to rely on the direct inhibition of DNA synthesis leading to suppression of cell proliferation.
Dashlkhumbe Byamba, Do-Young Kim, Chimidtseren Soodoi, Enkhtur Yadamsuren, Ariunaa Munkhbayar, Nandintsetseg Batbayar, Dashkhajidmaa Dashdondov, Oyuntsatsral Batsaikhan, Batbaatar Gunchin, Min-Geol Lee   +9 more
doaj   +1 more source

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Interleukin‐12/23 and Interleukin‐23 Inhibitors for the Treatment of Cutaneous Crohn's Disease: A Case Series From a Multi‐Institutional Registry

JEADV Clinical Practice
Background Cutaneous Crohn's disease (CCD) is a granulomatous condition of the skin discontiguous from the gastrointestinal tract. Cutaneous disease rarely correlates with intestinal disease and often requires separate treatment.
G. E. McKay, A. Coromilas, L. Liu, K. S. Shaw, M. Murphy, N. Punyamurthy, K. M. Santiago Soltero, W. Damsky, K. A. Wanat, A. P. Charrow, M. Rosenbach, A. Caplan, C. E. LaSenna, L. Arkin, B. E. Shields   +14 more
doaj   +1 more source

Interleukin-23 as a therapeutic target for inflammatory myopathy

Scientific Reports, 2018
AbstractCurrent treatments of polymyositis and dermatomyositis (PM/DM) depend on non-specific immunosuppressants. This study was performed to elucidate the role of interleukin (IL)-23, as their possible therapeutic target. As was reported earlier in PM/DM patients, serum IL-23 levels were elevated in mice with C protein induced-myositis (CIM), a murine
Umezawa, Natsuka, Kawahata, Kimito, Mizoguchi, Fumitaka, Kimura, Naoki, Yoshihashi-Nakazato, Yoko, Miyasaka, Nobuyuki, Kohsaka, Hitoshi   +6 more
openaire   +2 more sources

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk [PDF]

, 2011
<p><b>Objective:</b> The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD).</p> <p><b>Methods and Results:</b> In the ...
Jukema, J.W., Trompet, S., Sattar, N., David J. Stott, Jukema, J. Wouter, Heather M. Murray, Ian Ford, Ford, I., Welsh, Paul, Anton J.M. de Craen, McInnes, Iain B., Trompet, Stella, Paul Welsh, J. Wouter Jukema, Westendorp, Rudi G.J., McInnes, I.B., Welsh, P., Westendorp, R.G.J., Packard, C.J., Murray, H.M., Craen, A.J.M. de, de Craen, Anton J.M., Rudi G.J. Westendorp, Sattar, Naveed, Stella Trompet, Stott, David J., Naveed Sattar, Ford, Ian, Chris J. Packard, Murray, Heather M., PROSPER Study Grp, Packard, Chris J., Iain B. McInnes, Stott, D.J.   +33 more
core   +1 more source

Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study

Arthritis Care &Research, EarlyView.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023.
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata

, 2015
Objective To investigate the distribution of interleukin (IL)-12 (IL12; 1188A/C), IL17 (A7488G) and IL-23 receptor (IL23R; +2199A/C) gene polymorphisms in patients with alopecia ...
Pehlivan, Sacide, AYTEKIN, Nesrin, Akcali, Cenk, Kirtak, Necmettin, Inaloz, Serhat   +4 more
core   +1 more source

Interleukin-23 [PDF]

General Internal Medicine and Clinical Innovations, 2020
openaire   +3 more sources