Results 41 to 50 of about 535,272 (261)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Evaluation of Interleukin-21, 23 and 27 mRNA Expression and Protein Level in Liver Transplant Patients

Iranian Journal of Allergy, Asthma and Immunology, 2018
Cytokines have prominent roles in activating of different T cells and shifting the immune response, in this study the role of three cytokines (IL-21, IL-23 and IL-27) is investigated in the liver transplant rejection.
Afsoon Afshari, Ramin Yaghobi, Negar Azarpira, Bita Gerami Zadeh, Seyed Ali Malek Hosseini, Mojtaba Darbouy, Mohammad Hossein Karimi   +6 more
doaj   +1 more source

Association of Interleukin 23 Receptor Gene with Sarcoidosis [PDF]

Disease Markers, 2011
Interleukin 23 receptor (IL23R) gene has been reported as a genetic factor strongly associated with inflammatory bowel disease, psoriasis, and ankylosing spondylitis. We investigated the association betweenIL23Rgene single nucleotide polymorphisms (SNPs) and susceptibility to sarcoidosis, including the clinical manifestation of uveitis.Ninety-one ...
Hyun Soo Kim, Dongseok Choi, Lyndell L. Lim, Gopal Allada, Justine R. Smith, Carrie R. Austin, Trudy M. Doyle, Kelley A. Goodwin, James T. Rosenbaum, Tammy M. Martin   +9 more
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Uncovering how interleukin-5 and interleukin-23 shape human immune defense against Salmonella enterica Typhi

Journal of Microbiology and Infectious Diseases
Background: Salmonella enterica serotype Typhi remains a major global health concern, particularly in regions with limited resources. Interleukins such as interleukin-5 and interleukin-23 are thought to play pivotal roles in shaping the host's ...
Ruaa Kareem Surhan, Aqeel A. Al-Sadawi, Ali Reyadh Medhat, Ahmed Al Obaidi   +3 more
doaj   +1 more source

Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa- pilot study

Italian Journal of Pediatrics, 2019
Background Vitamin D plays an important role in inflammatory responses after antigen exposure. Interleukin-23 (Il-23) promotes Il-17-dependent inflammation during Pseudomonas aeruginosa (P. aeruginosa) pulmonary infection. We aimed to compare the ability
M. Olszowiec-Chlebna, A. Koniarek-Maniecka, A. Brzozowska, A. Błauż, B. Rychlik, I. Stelmach   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Perspectives on the Genetic Associations of Ankylosing Spondylitis

Frontiers in Immunology, 2021
Ankylosing spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex polygenic aetiology. Genome-wide association studies have identified more than 100 loci, including some involved in antigen presentation (HLA-B27, ERAP1, and ...
B. Paul Wordsworth, B. Paul Wordsworth, Carla J. Cohen, Connor Davidson, Matteo Vecellio, Matteo Vecellio, Matteo Vecellio   +6 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor [PDF]

Carcinogenesis, 2012
A proinflammatory cytokine, interleukin 23 (IL-23), plays a role in tumor progression by inducing inflammation in the tumor microenvironment, although there is debate about its role in carcinogenesis. Direct effects of IL-23 on tumor cells have been reported rarely, and contradictory effects have been observed. Here, we studied such effects of IL-23 in
Jun, Li, Le, Zhang, Jie, Zhang, Yuyan, Wei, Kai, Li, Lugang, Huang, Sen, Zhang, Bo, Gao, Xiujie, Wang, Ping, Lin   +9 more
openaire   +2 more sources