Gram-positive pathogenic bacteria induce a common early response in human monocytes [PDF]
, 2010 Background We infected freshly isolated human peripheral monocytes with live bacteria of three clinically important gram-positive bacterial species, Staphylococcus aureus, Streptococcus pneumoniae and Listeria monocytogenes and studied the ensuing early ...
Svetlin Tchatalbachev +3 more
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Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
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INTERLEUKIN -23, APPLICATION PROSPECTS (LITERATURE REVIEW)
Eurasian Journal of Medical and Natural Sciences, 2023 With the advent of new technologies, several new pro-inflammatory cytokines have been characterized, such as IL-23, which plays an important role in the pathogenesis of a number of inflammatory diseases. IL-23 pathways, as well as other proteins involved in the pathogenesis of inflammatory diseases, are currently under development and show promising ...
H.B. Mahamathojayeva +3 more
openaire +2 more sources
Interleukin 23 in the skin: role in psoriasis pathogenesis and selective interleukin 23 blockade as treatment [PDF]
Therapeutic Advances in Chronic Disease, 2018 Plaque psoriasis is one of the most common autoimmune skin diseases and is characterized by erythematous, scaly plaques. Many highly effective, targeted therapies have been developed as a result of an improved understanding of the pathogenesis of psoriasis. Using agents that target the central interleukin (IL)-23/IL-17 immune axis, this once difficult-
Tom C, Chan +2 more
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Interleukin 23 Levels Are Increased in Carotid Atherosclerosis [PDF]
Stroke, 2015 Background and Purpose— Interleukin (IL)-23 is a cytokine in the IL-12 family, mainly produced by antigen-presenting cells with a central role in inflammation. We hypothesize that IL-23 is also important in atherogenesis and investigate this in a population with carotid atherosclerosis. Methods—
Abbas, Azhar +18 more
openaire +3 more sources
Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]
, 2018 Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F. +3 more
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Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis [PDF]
, 2009 Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene
De Keyser, Filip +8 more
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Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. [PDF]
, 2015 Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), is characterized by CNS demyelination mediated by autoreactive T cells.
Deng, Wenbin +5 more
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Association between Interleukin-23 Receptor R381Q Gene. [PDF]
, 2015 The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the
Ganjalikhani Hakemi, Mazdak. +5 more
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γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. [PDF]
, 2018 γδ T cells have been implicated in inflammatory diseases as an important link between the innate and adaptive immune responses, however, their role in inflammatory arthritis remain unclear.
Adamopoulos, Iannis E +3 more
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