Results 221 to 230 of about 4,322,877 (234)

Mast cells produce interleukin-25 upon FcεRI-mediated activation

Blood, 2003
Interleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–producing cells.
Kei Ikeda, Hiroshi Nakajima, Kotaro Suzuki, Shin-ichiro Kagami, Koichi Hirose, Akira Suto, Yasushi Saito, Itsuo Iwamoto   +7 more
openaire   +1 more source

Interleukin-25 and Interleukin-33 as Mediators of Eosinophilic Inflammation in Chronic Rhinosinusitis

American Journal of Rhinology & Allergy, 2015
Background The initiating mediators of T-helper 2 inflammation, often seen in eosinophillic chronic rhinosinusitis (CRS), remains poorly understood. Interleukin (IL) 25, IL-33, and thymic stromal lymphopoietin (TSLP) are epithelial-derived cytokines implicated in the initiation of T-helper 2 inflammation and eosinophilia in other diseases.
M. Lam, L. Hull, Andrew Imrie, K. Snidvongs, D. Chin, E. Pratt, L. Kalish, R. Sacks, P. Earls, W. Sewell, R. Harvey   +10 more
semanticscholar   +3 more sources

Interleukin-25 Induces Pulmonary Arterial Remodeling via Natural Killer T Cell-Dependent Mechanisms

International Archives of Allergy and Immunology, 2013
Background: Recent studies have shown that prolonged Th2-type immune inflammation in the lung induces pulmonary arterial remodeling, in part through the induction of resistin-like molecule α (RELMα) expression. However, the role of interleukin-25 (IL-25; which promotes this inflammation) in the development of the pulmonary arterial remodeling remains ...
Saki Kawashima, K. Hirose, Kentaro Takahashi, T. Tamachi, K. Ikeda, K. Tokoyoda, T. Nakayama, H. Nakajima   +7 more
semanticscholar   +3 more sources

Interleukin-25: A two-edged sword in the control of immune-inflammatory responses

Cytokine & Growth Factor Reviews, 2010
Interleukin-25 (IL-25), the newest member of the IL-17 cytokine family, initiates, promotes, and augments Th2 cell-mediated immune responses, thereby contributing to allergic disease and defense against helminthic parasites. More recent studies have shown that IL-25 can control the functional activity of non-T cells and suppress the initiation and ...
MONTELEONE, GIOVANNI, PALLONE, FRANCESCO, Macdonald, TT   +2 more
openaire   +3 more sources

Interleukin-25: A Key Initiator of Type 2 Immune Responses

2013
T helper 2 (Th2) cells induce allergic inflammation through the production of Th2 cytokines such as interleukin (IL)-4, IL-5, and IL-13. In addition, it has been demonstrated that IL-25 (IL-17E) is involved in the initiation and amplification of type 2 immune responses. Recent studies have shown that a number of cell types including activated Th2 cells,
Hiroshi Nakajima, Tomohiro Tamachi, Koichi Hirose   +2 more
openaire   +1 more source

Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome

Blood, 2010
Abstract Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2).
Benjamin, Terrier, Ivan, Bièche, Thierry, Maisonobe, Ingrid, Laurendeau, Michèlle, Rosenzwajg, Jean-Emmanuel, Kahn, Marie-Claude, Diemert, Lucile, Musset, Michel, Vidaud, Damien, Sène, Nathalie, Costedoat-Chalumeau, Du, Le Thi-Huong, Zahir, Amoura, David, Klatzmann, Patrice, Cacoub, David, Saadoun   +15 more
openaire   +2 more sources

The Dual Role of Interleukin-25 in the Control of Immune-Mediated Pathologies

Current Molecular Medicine, 2011
Interleukin-25 (IL-25) plays a key role in the initiation and expansion of T helper (Th) 2 cell-mediated immune responses, thereby contributing to allergic diseases and host defense against helminthic parasites. More recent studies have however shown that IL-25 can also control the function of non-T cells, such as antigen presenting cells and ...
Caruso, R, Stolfi, C, De Nitto, D, Pallone, F, Monteleone, G   +4 more
openaire   +4 more sources

The Effect of Interleukin 25 on Human Th2 Lymphocytes

2014
CRTh2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) is a marker for Th2 cells and activation through CRTh2 stimulates expression of cytokines that are important for allergic responses such as IL-4, IL-5 and IL-13. We have observed CRTh2+ T cells express the IL-25 receptor (IL-25R). IL-25 is produced by the epithelium in response
openaire   +1 more source

Interleukin-25 Inhibits Interleukin-12 Production and Th1 Cell-Driven Inflammation in the Gut

Gastroenterology, 2009
During the pathogenesis of Crohn's disease (CD), interleukin (IL)-12, a cytokine produced by mucosal CD14+ monocyte-like cells, promotes tissue-damaging T helper cell (Th) 1-mediated inflammation through mechanisms that are not fully understood. IL-25 promotes Th2 cell responses by activating major histocompatibility complex class II-positive non-T and
Caruso, R, Sarra, M, Stolfi, C, Rizzo, A, Fina, D, FANTINI, MASSIMO CLAUDIO, PALLONE, FRANCESCO, MacDonald, TT, MONTELEONE, GIOVANNI   +8 more
openaire   +4 more sources

Interleukin-25 fails to activate STAT6 and induce alternatively activated macrophages.

Immunology, 2011
Interleukin-25 (IL-25), a T helper type 2 (Th2) -related factor, inhibits the production of inflammatory cytokines by monocytes/macrophages. Since Th2 cytokines antagonize classically activated monocytes/macrophages by inducing alternatively activated macrophages (AAMs), we here assessed the effect of IL-25 on the alternative activation of human ...
Stolfi, C, Caruso, R, Franzè, E, Sarra, M, De Nitto, D, Rizzo, A, Pallone, F, Monteleone, G   +7 more
openaire   +3 more sources