Results 261 to 270 of about 4,841,277 (301)

Interleukin-25 Negatively Controls Pathogenic Responses in the Gut

Inflammation & Allergy - Drug Targets, 2011
Although interleukin-25 (IL-25) has been traditionally considered as a cytokine involved in T helper (Th) 2 cell-associated allergic diseases and host defence against helminthic parasites, recent studies have shown that IL-25 exerts negative effects on the initiation and progression of Th1/Th17-mediated pathologies.
Eleonora, Franzè, Angelamaria, Rizzo, Roberta, Caruso, Francesco, Pallone, Giovanni, Monteleone   +4 more
openaire   +2 more sources

Interleukin-25: Key Regulator of Inflammatory and Autoimmune Diseases

Current Pharmaceutical Design, 2011
Polarization of naïve T cells in a certain functional direction is influenced not only by antigen type and concentration, but also by co-stimulatory signals, the local cytokine environment and transcription factors that activate or inhibit specific T cell lineage programs through positive or negative feedback loops. Interleukin-25 (IL-25) is a recently
David, Saadoun, Benjamin, Terrier, Patrice, Cacoub   +2 more
openaire   +2 more sources

Interleukin‐25 Axis Is Involved in the Pathogenesis of Human Primary and Experimental Murine Sjögren's Syndrome

Arthritis & Rheumatology, 2018
To investigate the role of the interleukin‐25 (IL‐25)/IL‐17 receptor B (IL‐17RB) axis in experimental Sjögren's syndrome (SS) and in patients with primary SS and primary SS–associated lymphoma.
G. Guggino, Xiang Lin, A. Rizzo, F. Xiao, L. Saieva, S. Raimondo, D. Di Liberto, G. Candore, P. Ruscitti, P. Cipriani, R. Giacomelli, F. Dieli, R. Alessandro, G. Triolo, Liwei Lu, F. Ciccia   +15 more
semanticscholar   +1 more source

Interleukin-25 is upregulated in patients with systemic lupus erythematosus and ameliorates murine lupus by inhibiting inflammatory cytokine production.

International Immunopharmacology, 2019
Interleukin-25 (IL-25), an anti-inflammatory member of the IL-17 family of cytokines, has been extensively investigated in multiple autoimmune and inflammatory diseases.
Yongsheng Li, Rui Wang, Shanshan Liu, Juan Liu, W. Pan, Fang Li, Ju Li, Deqian Meng   +7 more
semanticscholar   +1 more source

Mast cells produce interleukin-25 upon FcεRI-mediated activation

Blood, 2003
Interleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–producing cells.
Kei Ikeda, Hiroshi Nakajima, Kotaro Suzuki, Shin-ichiro Kagami, Koichi Hirose, Akira Suto, Yasushi Saito, Itsuo Iwamoto   +7 more
openaire   +1 more source

Interleukin-25 reduces Th17 cells and inflammatory responses in human peripheral blood mononuclear cells.

Human Immunology, 2018
BACKGROUND The absence of interleukin-25 (IL-25) favors the induction of Th1 and Th17 immune responses in mice. Th1 immune responses have been associated with the pathology of atherosclerosis, a lipid and inflammation driven disease of the arterial wall.
Polyxeni T. Mantani, Jenifer Vallejo, I. Ljungcrantz, J. Nilsson, H. Björkbacka, G. N. Fredrikson   +5 more
semanticscholar   +1 more source

Interleukin-25: A two-edged sword in the control of immune-inflammatory responses

Cytokine & Growth Factor Reviews, 2010
Interleukin-25 (IL-25), the newest member of the IL-17 cytokine family, initiates, promotes, and augments Th2 cell-mediated immune responses, thereby contributing to allergic disease and defense against helminthic parasites. More recent studies have shown that IL-25 can control the functional activity of non-T cells and suppress the initiation and ...
MONTELEONE, GIOVANNI, PALLONE, FRANCESCO, Macdonald, TT   +2 more
openaire   +3 more sources

Interleukin-25 and Interleukin-33 as Mediators of Eosinophilic Inflammation in Chronic Rhinosinusitis

American Journal of Rhinology & Allergy, 2015
Background The initiating mediators of T-helper 2 inflammation, often seen in eosinophillic chronic rhinosinusitis (CRS), remains poorly understood. Interleukin (IL) 25, IL-33, and thymic stromal lymphopoietin (TSLP) are epithelial-derived cytokines implicated in the initiation of T-helper 2 inflammation and eosinophilia in other diseases.
M. Lam, L. Hull, Andrew Imrie, K. Snidvongs, D. Chin, E. Pratt, L. Kalish, R. Sacks, P. Earls, W. Sewell, R. Harvey   +10 more
semanticscholar   +3 more sources

Interleukin-25: A Key Initiator of Type 2 Immune Responses

2013
T helper 2 (Th2) cells induce allergic inflammation through the production of Th2 cytokines such as interleukin (IL)-4, IL-5, and IL-13. In addition, it has been demonstrated that IL-25 (IL-17E) is involved in the initiation and amplification of type 2 immune responses. Recent studies have shown that a number of cell types including activated Th2 cells,
Hiroshi Nakajima, Tomohiro Tamachi, Koichi Hirose   +2 more
openaire   +1 more source

Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome

Blood, 2010
Abstract Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2).
Benjamin, Terrier, Ivan, Bièche, Thierry, Maisonobe, Ingrid, Laurendeau, Michèlle, Rosenzwajg, Jean-Emmanuel, Kahn, Marie-Claude, Diemert, Lucile, Musset, Michel, Vidaud, Damien, Sène, Nathalie, Costedoat-Chalumeau, Du, Le Thi-Huong, Zahir, Amoura, David, Klatzmann, Patrice, Cacoub, David, Saadoun   +15 more
openaire   +2 more sources