Interaction of STAT5 Dimers on Two Low Affinity Binding Sites Mediates Interleukin 2 (IL-2) Stimulation of IL-2 Receptor α Gene Transcription* [PDF]
Journal of Biological Chemistry, 1997 Stimulation of the interleukin 2 receptor α (IL-2Rα) gene by IL-2 is important for the proliferation of antigen-activated T lymphocytes. IL-2 regulates IL-2Rα transcription via a conserved 51-nucleotide IL-2 responsive enhancer.
W. Meyer +4 more
semanticscholar +2 more sources
The Morphopathogenetic Aspects of Intraabdominal Adhesions in Children under One Year of Age [PDF]
Medicina, 2019 Background and Objectives: The morphopathogenesis of adhesions is a complex process, characterized by the accumulation of an extracellular matrix, inflammation and hypoxia.
Anna Junga +3 more
doaj +3 more sources
Constitutive Binding of the Transcription Factor Interleukin-2 (IL-2) Enhancer Binding Factor to the IL-2 Promoter* [PDF]
Journal of Biological Chemistry, 1997 A positive regulatory element in the interleukin-2 (IL-2) promoter, designated the antigen receptor response element-2, is essential for the induction of IL-2 gene expression upon the binding of an inducible multiprotein complex of proteins known as ...
A. Nirula, D. J. Moore, R. Gaynor
semanticscholar +4 more sources
The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation.
Journal of Biological Chemistry, 1994 Binding of interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) stimulates Src family kinases, tyrosine phosphorylation of several proteins, conversion of Ras to its active GTP-bound form, and eventually c-fos, c-jun, and c-myc induction. The IL-2R beta chain plays a crucial role in IL-2R signaling.
K. Ravichandran, S. Burakoff
semanticscholar +4 more sources
Relationship Between Cysteine, Interleukin (Il)-2, and Interleukin (Il)-10 in Children with Marasmus Type Malnutrition [PDF]
Journal of Tropical Life Science, 2016 Malnutrition is one of the health issues in developing countries. The most commonly found malnutrition is the marasmus type. Infection in marasmus patient is the main cause of morbidity and mortality in developing countries.
Teguh Wahyudi +2 more
doaj +3 more sources
Angioneurotic oedema and urticaria during therapy with interleukin-2 (IL-2)
Annals of Oncology, 1992 Johanna W. Baars +5 more
openalex +4 more sources
RECOMBINANT CYTOKINES IN THE TREATMENT OF PNEUMONIA. CLINICAL EXPERIENCE
Interdisciplinary Approaches to Medicine, 2021 Antimicrobial chemotherapy is a keystone of the treatment of pneumonia. Prescription of antibacterial drugs does not always ensure the success of treatment due to the secondary immune deficiency developing in the process of the disease and the rapid ...
O.A. Gizinger +2 more
doaj +3 more sources
Frontiers in Immunology, 2021 Invariant NKT (iNKT) cells are thymus-generated innate-like T cells, comprised of three distinct subsets with divergent effector functions. The molecular mechanism that drives the lineage trifurcation of immature iNKT cells into the NKT1, NKT2, and NKT17
Hee Yeun Won +5 more
doaj +1 more source
Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation
Frontiers in Immunology, 2022 Cytokines are crucial molecules for maintaining the proper functioning of the immune system. Nevertheless, a dysregulation of cytokine expression could be involved in the pathogenesis of autoimmune diseases.
Dihia Meghnem +18 more
doaj +1 more source