Results 11 to 20 of about 548,596 (188)

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia [PDF]

Brazilian Journal of Medical and Biological Research, 2016
We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia.
W. Eik Filho, S.S. Marcon, T. Krupek, I.T.S. Previdelli, O.C.N. Pereira, M.A.R.C.P. Silva, R.B. Bazotte   +6 more
doaj   +3 more sources

Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy

Frontiers in Cell and Developmental Biology, 2020
The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules.
Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Isaac Narbona-Sánchez, Francisco García-Cózar, Francisco García-Cózar, Arkadiusz Miazek, Enrique Aguado, Enrique Aguado   +7 more
doaj   +1 more source

A systematic review of interleukin-2-based immunotherapies in clinical trials for cancer and autoimmune diseasesResearch in context

EBioMedicine, 2023
Summary: Background: The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and regulatory T (Treg) cells. The ability of selectively engaging either of these effects has spurred interest in using IL-2 for immunotherapy of cancer and
Miro E. Raeber, Dilara Sahin, Ufuk Karakus, Onur Boyman   +3 more
doaj   +1 more source

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. [PDF]

Proceedings of the National Academy of Sciences, 1985
We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2 receptor number is maximal within 12 hr, requires new RNA and protein synthesis, and is mediated by
J M, Depper, W J, Leonard, C, Drogula, M, Krönke, T A, Waldmann, W C, Greene   +5 more
openaire   +2 more sources

[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice

Frontiers in Immunology, 2022
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium.
Riikka Viitanen, Helena Virtanen, Heidi Liljenbäck, Heidi Liljenbäck, Olli Moisio, Xiang-Guo Li, Xiang-Guo Li, Xiang-Guo Li, Valeria Nicolini, Marine Richard, Christian Klein, Tapan Nayak, Sirpa Jalkanen, Sirpa Jalkanen, Anne Roivainen, Anne Roivainen, Anne Roivainen, Anne Roivainen   +17 more
doaj   +1 more source

Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75. [PDF]

The Journal of experimental medicine, 1990
We have recently established a mAb named TU11 mAb specific for the p75 subunit of human IL-2 receptor (IL-2R). The present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells. The tyrosine phosphorylation is mediated by the high affinity IL-2R, correlates with the IL-2-induced ...
H, Asao, T, Takeshita, M, Nakamura, K, Nagata, K, Sugamura   +4 more
openaire   +2 more sources

Lipoteichoic Acid Inhibits Interleukin-2 (IL-2) Function by Direct Binding to IL-2 [PDF]

Clinical Diagnostic Laboratory Immunology, 2001
ABSTRACTLipoteichoic acid (LTA) is associated with the cell envelope of most gram-positive bacteria. Although previously thought to act mainly as a virulence factor by virtue of its adhesive nature, evidence is now provided that LTA can also suppress the function of interleukin-2 (IL-2), an autocrine growth factor for T cells.
L M, Plitnick, R A, Jordan, J A, Banas, D M, Jelley-Gibbs, M C, Walsh, M T, Preissler, E J, Gosselin   +6 more
openaire   +2 more sources

Research on the Immunoregulatory Effect of Jujube Polysaccharide on Lymphocyte in Mice

Liang you shipin ke-ji, 2021
To study the immunomodulatory effect of jujube polysaccharide on mouse lymphocytes. Mouse lymphocytes were sterile separated， cell suspension was prepared， and the blank group， the positive group(levamisole) and the jujube polysaccharide group with ...
LI Feng-jiao, LI Jing-shuang, WANG Yi-lun, JIN Xin, LI Xian, YU Yang   +5 more
doaj   +1 more source

The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosoma cruzi infection causes Chagas’ disease in humans. The infection activates the innate and adaptative immunity in an orchestrated immune response to control parasite growth, guaranteeing host survival.
Jorge Nihei, Jorge Nihei, Fabiola Cardillo, Jose Mengel, Jose Mengel   +4 more
doaj   +1 more source

Interleukin-2 in Renal Cell Carcinoma: A Has-Been or a Still-Viable Option?

Journal of Kidney Cancer and VHL, 2014
Modulation of the immune response plays an important role in the natural history of renal cell carcinoma.  Spontaneous regression of metastases has been well documented in a small percentage of patients after they undergo de-bulking nephrectomy without ...
Asim Amin, Richard L White
doaj   +1 more source