Results 71 to 80 of about 1,240,457 (275)

Double-Edged Sword: Interleukin-2 Promotes T Regulatory Cell Differentiation but Also Expands Interleukin-13- and Interferon-γ-Producing CD8+ T Cells via STAT6-GATA-3 Axis in Systemic Lupus Erythematosus

Frontiers in Immunology, 2021
Interleukin-2 (IL-2) expands the depleted T regulatory (Treg) cell population, and it has emerged as a potential therapy in systemic lupus erythematosus (SLE). However, IL-2 administration may involve the risk of expanding unwanted pro-inflammatory cells.
Hiroshi Kato, Andras Perl
doaj   +1 more source

CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. [PDF]

, 1993
Type 1 and type 2 cloned T helper (Th) cells are believed to require different antigen-presenting cell (APC)-derived costimuli for proliferation. In the case of Th1-cloned T cells, CD28 signaling costimulates production of autocrine interleukin 2 (IL-2).
McArthur, JG, Raulet, DH
core  

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]

, 1994
Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core   +2 more sources

Examining the role of salivary IL-2 and IL-22 in recurrent aphthous stomatitis: a diagnostic approach

Journal of Ideas in Health
Background: Recurrent aphthous stomatitis (RAS) is a prevalent inflammatory condition, that manifests as mouth ulcers. This study aims to evaluate IL-2 and IL-22 levels in saliva samples of individuals with recurrent aphthous stomatitis (RAS) compared ...
Mustafa Taher
doaj   +3 more sources

Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells.

Blood, 1996
Natural killer (NK) cells are characterized by their ability to mediate spontaneous cytotoxicity against susceptible tumor cells and infected cells. They differentiate from hematopoietic progenitor cells.
M. Cavazzana‐Calvo, S. Hacein‐Bey, G. Basile, C. D. Coene, Françoise Selz, F. L. Deist, A. Fischer   +6 more
semanticscholar   +1 more source

An artificial CO-releasing metalloprotein built by histidine-selective metallation. [PDF]

, 2015
We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33.
,, ,, Albuquerque, IS, Bernardes, GJL, Boutureira, O, Chaves-Ferreira, M, Jeremias, HF, Matak-Vinkovic, D, Romão, CC   +8 more
core   +3 more sources

High-dose interleukin-2 (HD IL-2) for advanced melanoma: a single center experience from the University of Pittsburgh Cancer Institute

Journal for ImmunoTherapy of Cancer, 2017
Background Durable remissions are observed in a fraction of metastatic melanoma patients treated with high-dose interleukin-2 (HD IL-2). Early studies reported overall (OR) and complete response (CR) rates of 16% and 8% respectively. Toxicity limited use
Diwakar Davar, Fei Ding, Melissa Saul, Cindy Sander, Ahmad A. Tarhini, John M. Kirkwood, Hussein A. Tawbi   +6 more
doaj   +1 more source

Research progress of interleukin-15 in cancer immunotherapy

Frontiers in Pharmacology, 2023
Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is essential for the development, proliferation, and activation of immune cells, including natural killer (NK) cells, T cells and B cells.
Menghan Cai, Xuan Huang, Xuan Huang, Xiting Huang, Xiting Huang, Dianwen Ju, Dianwen Ju, Yi Zhun Zhu, Li Ye, Li Ye, Li Ye   +10 more
doaj   +1 more source

Increased production of interleukin-2 and IL-2 receptor in primary IgA nephropathy

Kidney International, 1989
The production of interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMC) in 13 patients with IgA nephropathy (IgAN) and 9 patients with chronic glomerulonephritis was investigated. Moreover, the distribution of IL-2 receptor (IL-2R) expression was studied in the purified T cell population versus the non-T cell population of IgAN patients ...
SCHENA FP, MASTROLITTI G, JIRILLO, Emilio, MUNNO I, FRACASSO AR, PELLEGRINO, Nelly Maria, AVENTAGGIATO, Lucia   +6 more
openaire   +3 more sources

Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer.

Blood, 1991
Peripheral eosinophilia is almost invariably observed during the course of interleukin-2 (IL-2) therapy and is frequently accompanied by the development of a capillary leak syndrome characterized by edema, weight gain, and oliguria.
Carol van Haelst Pisani, J. Kovach, H. Kita, K. Leiferman, Gerald, J., Gleich, J. Silver, R. Dennin, J. Abrams   +9 more
semanticscholar   +1 more source