Results 91 to 100 of about 2,108,740 (316)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Schizophrenia and Alarmins

Medicina, 2022
Schizophrenia, consisting of a group of severe psychiatric disorders with a complex etiology, is a leading cause of disability globally. Due to the lack of objective indicators, accurate diagnosis and selection of effective treatments for schizophrenia ...
Huan Ma, Ning Cheng, Caiyi Zhang
doaj   +1 more source

Downregulated miR-524-5p Participates in the Tumor Microenvironment of Ameloblastoma by Targeting the Interleukin-33 (IL-33)/Suppression of Tumorigenicity 2 (ST2) Axis

Medical Science Monitor, 2020
Background Ameloblastoma (AB) is a common odontogenic epithelial tumor, with locally invasive behavior and high recurrence. In this study, we hypothesized that miR-524-5p could be involved in the tumor microenvironment by targeting interleukin-33 (IL-33)/
Lijie Chen, Guannan Wang, Xue Qiao, Xiaobin Wang, Jinwen Liu, Xing Niu, M. Zhong   +6 more
semanticscholar   +1 more source

Biomarkers of Inflammation and Fibrosis in Kawasaki Disease Patients Years After Initial Presentation With Low Ejection Fraction. [PDF]

, 2020
Background Coronary artery aneurysms and myocarditis are well-recognized complications of Kawasaki disease (KD) but no systematic evaluation of the consequences of myocarditis has been performed in the subset presenting with low ejection fraction (EF ...
Burns, Jane C, He, Feng, Hoshino, Shinsuke, Jain, Sonia, Shimizu, Chisato, Tremoulet, Adriana H   +5 more
core  

Soluble ST2 levels and left ventricular structure and function in patients with metabolic syndrome [PDF]

, 2016
Background: A biomarker that is of great interest in relation to adverse cardiovascular events is soluble ST2 (sST2), a member of the interleukin family.
Beunza, Maite, Cardelli, Patrizia, Celic, Vera, Di Somma, Salvatore, Escribano, Elena, Floridi, Federico, Lopez-Andres, Natalia, Magrini, Laura, Majstorovic, Anka, Marino, Rossella, Melero, Amaia, Pencic-Popovic, Biljana, Roy, Ignacio, Salerno, Gerardo, Sljivic, Aleksandra   +14 more
core   +1 more source

The role of interleukin-33 in chronic rhinosinusitis [PDF]

Thorax, 2016
Interleukin (IL)-33, a new member of the IL-1 family, is constitutively expressed in epithelial tissues and lymphoid organs and plays an important role in the pathogenesis of allergic disease. However, the role of IL-33 in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear.To investigate the role of IL-33 in the pathophysiology of CRSwNP.
Dong-Kyu, Kim, Hong Ryul, Jin, Kyoung Mi, Eun, Ji-Hun, Mo, Seong H, Cho, Sohee, Oh, David, Cho, Dae Woo, Kim   +7 more
openaire   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Protein and mRNA expression of interleukin-33 in periodontally diseased and healthy individuals and impact of nonsurgical periodontal therapy in salivary IL-33 levels

Journal of Indian Society of Periodontology, 2023
Background: Interleukin (IL)-33 is a member of IL-1 beta family of cytokines having a pivotal role in bone destruction. However, its role in periodontal disease is not clearly established.
Ambili Renjith, Nisha Sushama Rajan, Shabnas Nazar Shaila   +2 more
doaj   +1 more source

Interleukin‐33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response

Immunology, 2020
Psoriasis is a chronic inflammatory skin disease with unclear pathogenesis. Interleukin‐33 (IL‐33) is highly expressed in patients with psoriasis, but its role in psoriasis is unknown.
Zeyu Chen, Yifan Hu, Yu Gong, Xi-lin Zhang, L. Cui, Rongfen Chen, Yingyuan Yu, Qian Yu, Youdong Chen, H. Diao, Jia Chen, Yuanyuan Wang, Yuling Shi   +12 more
semanticscholar   +1 more source