Results 131 to 140 of about 2,248,771 (288)
Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang +6 more
wiley +1 more source
Interleukin-33 : : Role in asthma and a promising inhibitor [PDF]
, 2013 Asthma is a disease of the airways for which the pathogenesis is still unknown. Recently, the Interleukin-1 (IL-1) family pair, IL-33 and its receptor ST2, has been implicated in asthma.
Magat, Jenna-Marie Emilia
core
Interleukin-1 superfamily member, interleukin-33, in periodontal diseases.
, 2014 Interleukin (IL)-33 is a nuclear protein that is released from damaged cells and acts as an alarmin. We investigated the expression of IL-33 in human gingival fibroblasts after stimulation by tumor necrosis factor alpha (TNF-alpha).
Memet, G. Tsaous, Beklen, ARZU
core +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Каразінський імунологічний журналBackground. Interleukin-33 is a promising biomarker of inflammation. Research into it could improve the diagnosis and treatment of chronic obstructive pulmonary disease.Purpose – to assess the diagnostic value of interleukin-33 by comparing it with
Bilko V.V. +3 more
doaj +1 more source
Die Interaktion der p53-Familienmitglieder p53 und p73 mit Interleukin 33 im humanen Kolorektalen Karzinom [PDF]
Mit über 10 % aller Tumorentitäten weltweit stellt das humane Kolorektale Karzinom eine, aus klinischer Sicht hochbedeutsame Entität dar. Dabei kann es über verschiedene Wege entstehen.
Wellenhofer, Maximilian Michael
core +1 more source
Advanced Science, EarlyView.This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu +13 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
The ST2/Interleukin-33 Axis in Hematologic Malignancies: The IL-33 Paradox
, 2019 Interleukin (IL)-33 is a chromatin-related nuclear interleukin that is a component of IL-1 family. IL-33 production augments the course of inflammation after cell damage or death. It is discharged into the extracellular space.
Vanessa Innao +6 more
core +1 more source