Results 31 to 40 of about 59,730,718 (209)

Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats

, 2023
Paracetamol (PAR) is a commonly used antipyretic and analgesic agent, but its excessive usage can induce liver damage and major health consequences.
Sultan Ayesh Mohammed Saghir, Mohammed Abdullah Alshawsh (9760803), Mouaadh Abdelkarim (17541390), Maisa Siddiq Abduh, Saleh Mohammad Aldaqal (17541393), Saleh Mohammad Aldaqal, Mouaadh Abdelkarim, Sultan Ayesh Mohammed Saghir (17541381), Naif Ahmed Al-Gabri, Ahmad Faheem Ahmeda, Ahmad Faheem Ahmeda (17541387), Maisa Siddiq Abduh (16381125), Naif Ahmed Al-Gabri (17541384), Mohammed Abdullah Alshawsh   +13 more
core   +1 more source

CD19+CD24highCD27+ B cell and interleukin 35 as potential biomarkers of disease activity in systemic lupus erythematosus patients

Advances in Rheumatology, 2022
Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that associates with aberrant activation of B lymphocytes and excessive autoantibodies.
Hui Xiong, Zengqi Tang, Ying Xu, Zhenrui Shi, Zhixuan Guo, Xiuting Liu, Guozhen Tan, Xuechen Ai, Qing Guo   +8 more
doaj   +1 more source

Level of interleukin-35 in patients with idiopathic membranous nephropathy and its predictive value for remission time

Frontiers in Immunology, 2022
ObjectiveAs a member of interleukin-12 family, interleukin-35 (IL-35) plays an important regulatory role in immune response. The relationship between IL-35 and idiopathic membranous nephropathy (IMN) is still unclear, and the purpose of this study is to ...
Na Zhang, Na Zhang, Haoran Dai, Xuan Dong, Xuan Dong, Wenbin Liu, Hanxue Jiang, Hanxue Jiang, Qihan Zhao, Qihan Zhao, Yu Gao, Yu Gao, Zhendong Feng, Zhendong Feng, Zhaocheng Dong, Zhaocheng Dong, Yuehong Hu, Yuehong Hu, Guangrui Huang, Hongliang Rui, Hongliang Rui, Baoli Liu, Baoli Liu   +22 more
doaj   +1 more source

Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance

Cell Reports, 2017
Summary: Regulatory T cells (Tregs) can exert their functions through multiple suppressive mechanisms; however, it is unclear how Tregs exactly employ these mechanisms.
Xundong Wei, Jianhua Zhang, Qianchong Gu, Man Huang, Wei Zhang, Jie Guo, Xuyu Zhou   +6 more
doaj   +1 more source

High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis

Frontiers in Immunology
BackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang, Yaxiong Li, Li Zhao, Bin Liu, Zhibin Cai, Peng Zhang, Peng Li, Xuezhen Gao, Yong Zhan   +8 more
doaj   +1 more source

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]

, 2010
If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow, Kind, Peter, Rudloff, Ina, Klaus-Peter Hunfeld, Katharina Horn, Itamar Goren, Urs Christen, Kraiczy Peter, Horn Katharina, Pfeilschifter, Josef (Prof. Dr.), Mühl Heiko, Koehl Ulrike, Peter Kind, Goren Itamar, Peter Kraiczy, Rudloff Ina, Goren, Itamar, Mühl, Heiko, Darsow, Nicole, Christen Urs, Kraiczy, Peter, Christen, Urs, Holdener, Martin, Horn, Katharina, Hunfeld, Klaus-Peter, Ulrike Koehl, Hunfeld Klaus-Peter, Heiko Mühl, Ina Rudloff, Malte Bachmann, Martin Holdener, Holdener Martin, Bachmann Malte, Darsow Nicole, Kind Peter, Köhl, Ulrike, Josef Pfeilschifter, Bachmann, Malte, Pfeilschifter Josef   +38 more
core   +1 more source

CD27 and IL-35 as diagnostic biomarkers in alopecia areata: First evidence of association with pathogenic scalp bacterial infections

Babcock University Medical Journal
Objective: This study aimed to investigate the diagnostic and prognostic potential of CD27 and interleukin-35 (IL-35) in patients with Alopecia Areata (AA), with and without pathogenic bacterial infections.
Sura Mohammed Shakir, Layla Saleh Abdul-Hassan   +1 more
doaj   +1 more source

Interleukin-35 in autoimmune dermatoses: Current concepts

Open Medicine, 2022
Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal ...
Xie Yuming, Zhang Huilin, Huang Junke, Zhang Qing   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Interleukin-35 -producing B cells rescues inflammatory bowel disease in a mouse model via STAT3 phosphorylation and intestinal microbiota modification

Cell Death Discovery, 2023
Interleukin-35 (IL-35)-producing B cells (IL-35+B cells) play an important role in diseases, and the expansion of IL-35+ immune cells have been observed in inflammatory bowel disease (IBD). However, how IL-35+B cells function and the manner in which they
Minxiang Xie, Yuzhen Zhu, Yunjiao Zhou, Qiao Wang, Erli Gu, Yiwei Chu, Luman Wang   +6 more
doaj   +1 more source