Interleukin 35: protective role and mechanism in type 1 diabetes [PDF]
Central European Journal of Immunology, 2023 Interleukin 35 (IL-35), a cytokine secreted by regulatory T (Treg) cells from the differentiation of conventional CD4+ T cells, is a member of the IL-12 family. The IL-12 family of cytokines exhibits an anti-inflammatory property. IL-35 has recently been
Si-Ming Zhang +8 more
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Interleukin-35 pathobiology in periodontal disease: a systematic scoping review [PDF]
BMC Oral Health, 2021 Background Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 mediates immunological functions and plays a protective role in several diseases such as asthma and rheumatoid arthritis. However, the role
Patrick R. Schmidlin +2 more
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The diagnostic value of interleukin 35 as a septic biomarker: A meta-analysis [PDF]
Frontiers in Medicine, 2022 BackgroundThere is growing evidence that interleukin 35 (IL-35) represents a potential diagnostic biomarker for sepsis. The purpose of this meta-analysis was to evaluate the overall diagnostic accuracy of IL-35 in sepsis.Materials and methodsFrom October
Yuanhui Hu, Dongling Tang, Pingan Zhang
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Reduced circulating interleukin 35 is associated with enhanced peripheral T cell function in primary biliary cholangitis [PDF]
Biomolecules & Biomedicine, 2023 Interleukin 35 (IL-35) mediates immunosuppression of T cells in autoimmune diseases. T cells play an important role in primary biliary cholangitis (PBC) with incompletely elucidated pathogenesis. Thus, we aimed to investigate the role of IL-35 regulation
Siqi Liu +6 more
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Interleukin-35 in autoimmune dermatoses: Current concepts [PDF]
Open Medicine, 2022 Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal ...
Xie Yuming +3 more
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High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis [PDF]
Frontiers in ImmunologyBackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang +8 more
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Interleukin 35 promotes progression of hepatocellular carcinoma by recruiting neutrophils [PDF]
Translational OncologyBackground: A growing number of therapeutic strategies against hepatocellular carcinoma (HCC) have emerged. However, their efficacy remains limited.
Wei Gan +8 more
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Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis [PDF]
Frontiers in Pharmacology, 2021 It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration ...
Pan Lin Xin +4 more
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Immunomodulatory cytokine interleukin-35 and immune thrombocytopaenia [PDF]
Journal of International Medical Research, 2020 Considerable attention has been paid to interleukin (IL)-35 because of its immunosuppressive effects in a variety of autoimmune diseases. IL-35, a recently identified cytokine of the IL-12 family, is a negative regulatory factor secreted by IL-35 ...
Jing-Jing Zhu, Ning-Ning Shan
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Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis [PDF]
Frontiers in Endocrinology, 2021 ObjectiveOsteoporosis is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the suppressive role of interleukin (IL)-35 in nuclear factor kappa-B ligand receptor activator (RANKL) and ...
Hui Zhang +7 more
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