Results 1 to 10 of about 59,730,718 (209)
Interleukin 35: protective role and mechanism in type 1 diabetes
Central European Journal of Immunology, 2023 Interleukin 35 (IL-35), a cytokine secreted by regulatory T (Treg) cells from the differentiation of conventional CD4+ T cells, is a member of the IL-12 family. The IL-12 family of cytokines exhibits an anti-inflammatory property. IL-35 has recently been
Si-Ming Zhang +8 more
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Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. [PDF]
PLoS ONE, 2014 The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35.
Samadhi Aparicio-Siegmund +10 more
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Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study [PDF]
Mediators of Inflammation, 2017 Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms ofIL-12AandEBI3genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals.
Rosalinda Posadas-Sánchez +8 more
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The diagnostic value of interleukin 35 as a septic biomarker: A meta-analysis
Frontiers in Medicine, 2022 BackgroundThere is growing evidence that interleukin 35 (IL-35) represents a potential diagnostic biomarker for sepsis. The purpose of this meta-analysis was to evaluate the overall diagnostic accuracy of IL-35 in sepsis.Materials and methodsFrom October
Yuanhui Hu, Dongling Tang, Pingan Zhang
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Frontiers in Immunology, 2021 Interleukin (IL)-35-secreting B (IL-35+B) cells are critical regulators in autoimmune and infectious diseases and exert suppressive functions in parallel with IL-10-producing B (B10) cells.
YaYun Liu +6 more
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Pancreatic cancer: Emerging field of regulatory B-cell-targeted immunotherapies
Frontiers in Immunology, 2023 Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is characterized by a high mortality rate and poor prognosis.
Zeynep Nur Senturk +3 more
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IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14) [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018 Objective— IL-35 (interleukin-35) is an anti-inflammatory cytokine, which inhibits immune responses by inducing regulatory T cells and regulatory B cells and suppressing effector T cells and macrophages. It remains unknown whether atherogenic stimuli induce IL-35 and whether IL-35 inhibits atherogenic lipid ...
Xinyuan, Li +13 more
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Allergy, Asthma & Clinical Immunology, 2021 Background IL-35 is a newly anti-inflammatory cytokine that belongs to the IL-12 family. Mast cells, as one of the major effector cells in the immune response system, plays an important role in the pathogenesis of chronic spontaneous urticarial (CSU ...
Li-xin Fu +4 more
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Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis
Frontiers in Pharmacology, 2021 It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration ...
Pan Lin Xin +4 more
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Frontiers in Immunology, 2023 Although psoriasis is classified as a T cell-mediated inflammatory disease, the contribution of myeloid cells to the pathogenesis of psoriasis is not fully understood.
Junfeng Zhang +18 more
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