Interleukin 35: protective role and mechanism in type 1 diabetes [PDF]
Central European Journal of Immunology, 2023 Interleukin 35 (IL-35), a cytokine secreted by regulatory T (Treg) cells from the differentiation of conventional CD4+ T cells, is a member of the IL-12 family. The IL-12 family of cytokines exhibits an anti-inflammatory property. IL-35 has recently been
Si-Ming Zhang +8 more
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Interleukin-35 pathobiology in periodontal disease: a systematic scoping review [PDF]
BMC Oral Health, 2021 Background Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 mediates immunological functions and plays a protective role in several diseases such as asthma and rheumatoid arthritis. However, the role
Patrick R. Schmidlin +2 more
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The diagnostic value of interleukin 35 as a septic biomarker: A meta-analysis [PDF]
Frontiers in Medicine, 2022 BackgroundThere is growing evidence that interleukin 35 (IL-35) represents a potential diagnostic biomarker for sepsis. The purpose of this meta-analysis was to evaluate the overall diagnostic accuracy of IL-35 in sepsis.Materials and methodsFrom October
Yuanhui Hu, Dongling Tang, Pingan Zhang
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Interleukin-35 in autoimmune dermatoses: Current concepts [PDF]
Open Medicine, 2022 Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal ...
Xie Yuming +3 more
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High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis [PDF]
Frontiers in ImmunologyBackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang +8 more
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Reduced circulating interleukin 35 is associated with enhanced peripheral T cell function in primary biliary cholangitis [PDF]
Biomolecules & Biomedicine, 2023 Interleukin 35 (IL-35) mediates immunosuppression of T cells in autoimmune diseases. T cells play an important role in primary biliary cholangitis (PBC) with incompletely elucidated pathogenesis. Thus, we aimed to investigate the role of IL-35 regulation
Siqi Liu +6 more
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Interleukin 35 promotes progression of hepatocellular carcinoma by recruiting neutrophils [PDF]
Translational OncologyBackground: A growing number of therapeutic strategies against hepatocellular carcinoma (HCC) have emerged. However, their efficacy remains limited.
Wei Gan +8 more
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Immunomodulatory cytokine interleukin-35 and immune thrombocytopaenia [PDF]
Journal of International Medical Research, 2020 Considerable attention has been paid to interleukin (IL)-35 because of its immunosuppressive effects in a variety of autoimmune diseases. IL-35, a recently identified cytokine of the IL-12 family, is a negative regulatory factor secreted by IL-35 ...
Jing-Jing Zhu, Ning-Ning Shan
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Plasma Interleukin-35 Levels Predict the Prognosis in Patients with HBV-Related Acute-on-Chronic Liver Failure [PDF]
VirusesThis study aimed to investigate the impact of IL-35 on the prognosis of patients with HBV-ACLF. We recruited 69 patients with HBV-ACLF, 20 patients with chronic hepatitis B (CHB), 17 patients with liver cirrhosis (LC), and 20 healthy controls (HCs) from ...
Liujuan Ji +10 more
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Association Between Interleukin 35 Gene Single Nucleotide Polymorphisms and the Uveitis Immune Status in a Chinese Han Population [PDF]
Frontiers in Immunology, 2021 Autoimmune uveitis is characterized by immune disorders of the eyes and the whole body and is often recurrent in young adults, but its pathogenesis is still unclear.
Meng Feng +13 more
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