Interleukin 35: protective role and mechanism in type 1 diabetes [PDF]
Central European Journal of Immunology, 2023 Interleukin 35 (IL-35), a cytokine secreted by regulatory T (Treg) cells from the differentiation of conventional CD4+ T cells, is a member of the IL-12 family. The IL-12 family of cytokines exhibits an anti-inflammatory property. IL-35 has recently been
Si-Ming Zhang +8 more
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Interleukin-35 pathobiology in periodontal disease: a systematic scoping review [PDF]
BMC Oral Health, 2021 Background Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 mediates immunological functions and plays a protective role in several diseases such as asthma and rheumatoid arthritis. However, the role
Patrick R. Schmidlin +2 more
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The diagnostic value of interleukin 35 as a septic biomarker: A meta-analysis [PDF]
Frontiers in Medicine, 2022 BackgroundThere is growing evidence that interleukin 35 (IL-35) represents a potential diagnostic biomarker for sepsis. The purpose of this meta-analysis was to evaluate the overall diagnostic accuracy of IL-35 in sepsis.Materials and methodsFrom October
Yuanhui Hu, Dongling Tang, Pingan Zhang
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Interleukin-35 in autoimmune dermatoses: Current concepts [PDF]
Open Medicine, 2022 Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family. IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal ...
Xie Yuming +3 more
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High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis [PDF]
Frontiers in ImmunologyBackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang +8 more
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Reduced circulating interleukin 35 is associated with enhanced peripheral T cell function in primary biliary cholangitis [PDF]
Biomolecules & Biomedicine, 2023 Interleukin 35 (IL-35) mediates immunosuppression of T cells in autoimmune diseases. T cells play an important role in primary biliary cholangitis (PBC) with incompletely elucidated pathogenesis. Thus, we aimed to investigate the role of IL-35 regulation
Siqi Liu +6 more
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Interleukin 35 promotes progression of hepatocellular carcinoma by recruiting neutrophils [PDF]
Translational OncologyBackground: A growing number of therapeutic strategies against hepatocellular carcinoma (HCC) have emerged. However, their efficacy remains limited.
Wei Gan +8 more
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Immunomodulatory cytokine interleukin-35 and immune thrombocytopaenia [PDF]
Journal of International Medical Research, 2020 Considerable attention has been paid to interleukin (IL)-35 because of its immunosuppressive effects in a variety of autoimmune diseases. IL-35, a recently identified cytokine of the IL-12 family, is a negative regulatory factor secreted by IL-35 ...
Jing-Jing Zhu, Ning-Ning Shan
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Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis [PDF]
Frontiers in Endocrinology, 2021 ObjectiveOsteoporosis is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the suppressive role of interleukin (IL)-35 in nuclear factor kappa-B ligand receptor activator (RANKL) and ...
Hui Zhang +7 more
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Plasma Interleukin-35 Levels Predict the Prognosis in Patients with HBV-Related Acute-on-Chronic Liver Failure [PDF]
VirusesThis study aimed to investigate the impact of IL-35 on the prognosis of patients with HBV-ACLF. We recruited 69 patients with HBV-ACLF, 20 patients with chronic hepatitis B (CHB), 17 patients with liver cirrhosis (LC), and 20 healthy controls (HCs) from ...
Liujuan Ji +10 more
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