Exploring the role of interleukin-27 as a regulator of neuronal survival in central nervous system diseases [PDF]
Neural Regeneration Research, 2022 Interleukin-27 is a pleiotropic cytokine that is involved in tissue responses to infection, cell stress, neuronal disease, and tumors. Recent studies in various tissues indicate that interleukin-27 has complex activating and inhibitory properties in ...
Andrea N Nortey +2 more
doaj +3 more sources
Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia [PDF]
OncoImmunology, 2023 Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic ...
Iria Fernandez Botana +3 more
doaj +5 more sources
Interleukin-27 in Tuberculosis: A Sheep in Wolf’s Clothing? [PDF]
Frontiers in Immunology, 2022 In tuberculosis (TB), protective inflammatory immune responses and the pathological sequelae of chronic inflammation significantly depend on a timely balance of cytokine expression.
Kristina Ritter +3 more
doaj +4 more sources
Prognostic Impact of Interleukin-27 in Peripheral Artery Disease [PDF]
LifeAtherosclerosis is a progressive arterial disease characterized by chronic inflammation, with interleukin-27 (IL-27) implicated as both a pro- and anti-inflammatory cytokine. This prospective cohort study evaluated association of circulating IL-27 levels
Nataša Kokalj, Borut Jug
doaj +6 more sources
Interleukin-27 levels in patients with myasthenia gravis [PDF]
Translational Neuroscience, 2020 Interleukin-27 (IL-27), which belongs to IL-12 family, influences the function of T cells (Tregs) through regulating the expression, and function of forkhead box P3 (FoxP3).
Liu Xiao-Jiao +8 more
doaj +3 more sources
Decreased levels of interleukin 27 in the serum of vitiligo patients, [PDF]
Anais Brasileiros de Dermatologia, 2020 Background: Vitiligo is a common skin disorder in which melanocytes are destroyed by auto-reactive immune responses. The loss of melanocytes results in the appearance of depigmented areas in different parts of the body. Cytokines have remarkable roles in
Saeed Malek Hosseini +3 more
doaj +5 more sources
The value of interleukin-27 for differentiating tuberculous pleural effusion from Mycoplasma pneumoniae pneumonic effusion in children [PDF]
Frontiers in Pediatrics, 2022 ObjectivesThe early diagnosis of tuberculous pleural effusion (TPE) is challenging due to the difficulty of isolating Mycobacterium tuberculosis, and pleural biomarkers are an optional choice.
Hui Xu +7 more
doaj +2 more sources
Immune Regulation of Interleukin-27 in Malignant Pleural Effusion
Chinese Medical Journal, 2015 Background: Interleukin (IL)-27 has been reported to have anti-proliferate and anti-angiogenic activities on cancer cells. However, the involvement of IL-27 in malignant pleural effusion (MPE) remains unknown.
Shi Li +4 more
doaj +3 more sources
Interleukin 27 Serum Level And Its Prognostic Significance In Children With Immune Thrombocytopenia [PDF]
Zagazig University Medical Journal, 2020 Aim of the work: was to determine the level of IL-27 in patients with immune thrombocytopenia and its relationship to demographic,clinical and laboratory characteristics of patients as well as disease chronicity and response to treatment. Methods: A case
Tamer Hassan +3 more
doaj +1 more source
Modulation of inflammation by interleukin-27 [PDF]
Journal of Leukocyte Biology, 2013 ABSTRACTA growing body of evidence suggests an essential role of the heterodimeric cytokine, IL-27, for regulating immunity. IL-27 is composed of two subunits (p28 and EBI3) and is classified as a member of the IL-12 family of cytokines. APCs have been recognized as a major cellular source of IL-27 following activation with microbial products or IFNs ...
Bosmann, Markus, Ward, Peter A.
openaire +3 more sources