Study on the Correlation between Interleukin-27 and CXCL10 in Pulmonary Tuberculosis [PDF]
Journal of Immunology Research, 2022 Objective. To investigate the correlation between interleukin-27 and CXCL10 and other cytokines in pulmonary tuberculosis and to further explore the related miRNAs through bioinformatics. Methods.
Jiahui Fan +9 more
doaj +3 more sources
Mathematical modeling of interleukin-27 induction of anti-tumor T cells response. [PDF]
PLoS ONE, 2014 Interleukin-12 is a pro-inflammatory cytokine which promotes Th1 and cytotoxic T lymphocyte activities, such as Interferon-[Formula: see text] secretion. For this reason Interleukin-12 could be a powerful therapeutic agent for cancer treatment.
Kang-Ling Liao +2 more
doaj +2 more sources
Interleukin 27 deficiency drives dilated cardiomyopathy by ferroptosis [PDF]
Clinical and Translational MedicineYan Zhao +9 more
doaj +4 more sources
Antiviral Response and Immunopathogenesis of Interleukin 27 in COVID-19 [PDF]
Archives of Virology, 2023 Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with a high mortality rate. The clinical course is attributed to the severity of pneumonia and systemic complications.
Juan Felipe Valdés‐López +1 more
europepmc +5 more sources
Interleukin-27 in T Cell Immunity [PDF]
International Journal of Molecular Sciences, 2015 Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells.
Iwasaki, Yukiko +3 more
openaire +3 more sources
Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil? [PDF]
Frontiers in Immunology, 2022 The occurrence and development of rheumatoid arthritis (RA) is regulated by numerous cytokines. Interleukin 27 (IL-27) is a soluble cytokine that exerts biological effects by regulating the Janus tyrosine kinase (JAK)/signal transducer and activator of ...
Liang Han +14 more
doaj +2 more sources
Interleukin-27-dependent transcriptome signatures during neonatal sepsis [PDF]
Frontiers in Immunology, 2023 Human newborns exhibit increased vulnerability and risk of mortality from infection that is consistent with key differences in the innate and adaptive immune responses relative to those in adult cells.
Jessica M. Povroznik +10 more
doaj +2 more sources
Association between interleukin-27 gene polymorphisms and Malaria [PDF]
Innate Immunity, 2023 Malaria is often characterized by a complicated disease course due to multifaceted intrinsic genetic factors of the host and the parasite. This study aimed to investigate the role of interleukin-27 ( IL-27 ) gene polymorphisms in Plasmodium falciparum ...
Nada H. Aljarba +10 more
doaj +2 more sources
Antiviral Activities of Interleukin-27: A Partner for Interferons? [PDF]
Frontiers in Immunology, 2022 Emergence of new, pandemic-level viral threats has brought to the forefront the importance of viral immunology and continued improvement of antiviral therapies.
Heather Amsden +3 more
doaj +2 more sources
Diagnostic performance of interleukin-27 and C-reactive protein in neonatal sepsis: an updated systematic review and meta-analysis [PDF]
Frontiers in PediatricsBackgroundInterleukin-27 (IL-27) has been proposed as a promising diagnosis marker for neonatal sepsis. However, findings across existing clinical studies remain inconsistent and inconclusive.
Wei Liu, Yan Zhang, Weidong Liu, Jun Luo
doaj +2 more sources