Results 91 to 100 of about 1,628,367 (268)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Estimation of Some Pro- and Anti-Inflammatory Interleukins in Rheumatoid Arthritis of Iraqi Patients

Medical Journal of Babylon
Background:Rheumatoid arthritis (RA) is an inflammatory condition that mostly affects synovial joints. It produces severe swelling and ongoing inflammation, and as it worsens, the cartilage and bone begin to erode, resulting in deformed joints and bone ...
Zahraa Jabbar Diwan, Wasan Addai Al-Marsomy   +1 more
doaj   +1 more source

Interleukin-6 polymorphisms in HCC patients chronically infected with HCV

Infectious Agents and Cancer, 2020
Hepatocellular carcinoma is a primary liver malignancy in which the risk of development is always multifunctional. Interleukin-6 is a proinflammatory and multifunctional cytokine, which plays an important role in the immune response, haematopoiesis and ...
Faisal Adnan, Najeeb Ullah Khan, Aqib Iqbal, Ijaz Ali, Arnolfo Petruzziello, Rocco Sabatino, Annunziata Guzzo, Giovanna Loquercio, Gerardo Botti, Sanaullah Khan, Muhammad Naeem, Muhammad Ismail Khan   +11 more
doaj   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential. [PDF]

, 2019
The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most recently discovered IL-36α, β, γ, IL-37, and IL-38. Similar to IL-1, IL-36 cytokines are initiators and amplifiers of inflammation, whereas both IL-37 and IL-38 ...
Alessandra Nerviani, Batliwalla, Costantino Pitzalis, Debets, Goldring, Marie-Astrid Boutet   +5 more
core   +1 more source

Achieving sustained minimal disease activity with methotrexate in early interleukin 23-driven early psoriatic arthritis [PDF]

, 2020
OBJECTIVES: Methotrexate (MTX) is currently the recommended first-line therapy for treating psoriatic arthritis (PsA), despite lacking clear evidence.
Bangoer, P.S. (Priyanka S.), Davelaar, N. (Nadine), den Braanker, H. (Hannah), Hazes, J.M.W. (Mieke), Kok, M.R. (Marc R.), Lubberts, E.W. (Erik), Luime, J.J. (Jolanda), Mus, A.M.C. (Adriana), Tchetverikov, I. (Ilja), Vis, M. (Marijn), Wervers, K. (Kim)   +10 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Interleukin-33 as a Potential Biomarker for Rheumatoid Arthritis: A Cross-Sectional Study [PDF]

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects about 1% of the general population. It is characterized by chronic, progressive, and systemic inflammation. Interleukin-33 (IL-33), is a pro-inflammatory cytokine that is
Alasady, Raad Abdulameer, Alsherees, Hashim Ali, Khamees, Mays Saleh   +2 more
core   +2 more sources

The protective role of muscone in the development of COPD

Frontiers in Immunology
BackgroundMuscone, a key component of musk, exhibits anti-inflammatory properties. However, its therapeutic potential in inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), remains largely unexplored.
Tiantian Feng, Xiaolong Guo, Wei Chen, Yanying Zhang, Runjing Dai, Yinfang Zhang, Yongqi Liu, Yiya Liu, Peng Song, Jingchun Fan   +9 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source