Results 131 to 140 of about 1,628,367 (268)

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

open access: yesAdvanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song   +8 more
wiley   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo   +11 more
wiley   +1 more source

Salt‐Compact Albumin as a New Pure Protein‐based Biomaterials: From Design to In Vivo Studies

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
A new class of materials built entirely of native albumin protein is designed using a simple protocol based on salt‐assisted compaction, breaking with current crosslinking strategies. This green process leads, surprisingly, to water‐insoluble handable materials with high preservation of their native protein structures and Young's modulus close to that ...
Eya Aloui   +19 more
wiley   +1 more source

Prevalence and Risk Factors of Pulmonary Embolism in COPD Patients Complicated with Secondary Polycythemia [PDF]

open access: yes
Jimei Li,* Yulin Xiong,* Shengyan Li, Qiong Ye, Yan Han, Xiuxin Zhang, Tongxiu Zhao, Yuan Yang, Xiaoshan Cui, Yinglan Li General Medicine Department, Qinghai Provincial People’s Hospital, Xining, Qinghai, People’s Republic of China*These ...
Cui X   +9 more
core   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

open access: yesAdvanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto   +2 more
wiley   +1 more source

Screening for tuberculosis infection and effectiveness of preventive treatment among people with HIV in low-incidence settings [PDF]

open access: yes
OBJECTIVE: To determine the yield of screening for latent tuberculosis infection (LTBI) among people with HIV (PWH) in low tuberculosis (TB) incidence countries (
Arts, RJW   +8 more
core  

The role of IL-36 and 37 in hepatocellular carcinoma [PDF]

open access: yes
Hepatocellular carcinoma (HCC) has garnered considerable attention due to its morbidity and mortality. Although the precise mechanisms underlying HCC tumorigenesis remain to be elucidated, evidence suggests that host immunity plays a pivotal role in its ...
Gui-Sen Zheng   +7 more
core   +1 more source

Impact of chronic hyperglycaemia on the coronary microcirculation - benefits of targeting IL-36 and diet reversal [PDF]

open access: yes
Following myocardial infarction (MI), patients with type 2 diabetes mellitus (T2DM) have poorer prognosis which may be linked to increased susceptibility of coronary microvessels to injury.
Cleary, Simon   +6 more
core   +2 more sources

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