Results 11 to 20 of about 417,692 (230)

Elevated serum Interleukin-39 in Myasthenia gravis: a possible biomarker

European Journal of Medical Research
Background Interleukin-39 (IL-39) is a cytokine implicated in immune regulation and autoimmune diseases, but its role in myasthenia gravis (MG) is unknown. This study aimed to investigate serum IL-39 levels in MG patients. Methods Serum IL-39 levels were
Kun Jia, Yingzhe Shao, Xuan Liu, Qiuxia Zhang, Li Yang   +4 more
doaj   +3 more sources

Association between salivary and serum Interleukin-39 and osteopontin in periodontitis patients: case-control study

Journal of Baghdad College of Dentistry
Background: Cytokines have a crucial role in developing chronic inflammation and the inflammatory response. Some interleukins, such as interleukin-39 (IL-39), have unknown specific roles in the pathogenesis of periodontitis.
Sarah J Al Lami, Ban AL-Drobie , Anas Salami   +2 more
doaj   +2 more sources

Interleukin 39: a new member of interleukin 12 family. [PDF]

Cent Eur J Immunol, 2020
Interleukin (IL)-12 family member is a heterodimer glycoprotein, composed of two covalently linked subunits, a and b chains. The a subunit consists of IL-23p19, IL-27p28, and IL-12p35, and the b subunit includes IL-12p40 and Epstein-Barr virus-induced gene (Ebi3).
Lu Z, Xu K, Wang X, Li Y, Li M.
europepmc   +3 more sources

Interleukin-37 and interleukin-39 as novel immunometabolic biomarkers in metabolic syndrome: A cross-sectional study. [PDF]

Medicine (Baltimore)
Metabolic syndrome (MetS) is characterized by abdominal obesity, dyslipidemia, hypertension, and insulin resistance, all driven by chronic low-grade inflammation. This study aimed to evaluate serum interleukin-37 (IL-37) and interleukin-39 (IL-39) levels as potential immunometabolic biomarkers in MetS.
Keskin L, Kiran TR, Erdem M, İnceoğlu F.   +3 more
europepmc   +3 more sources

A Role of Serum Interleukin-39 and Association with Small and Non-Small Cell Carcinoma in Lung Cancer Patients. [PDF]

Asian Pac J Cancer Prev
Lung cancer is the second most common malignancy globally and the leading cause of cancer-related deaths. Interleukin-39 (IL-39), a member of the IL-12 family secreted by B cells, acts as a pro-inflammatory cytokine and induces IL-23p19 expression in endothelial cells. Recent findings suggest reduced IL-39 expression in autoimmune thyroid disorders and
Addai Ali H, Hatif Hammood N, Saleh Mashkour M, Adday Ali R, Abdulameer Noman W, R Al-Ameer L, F Karam F, Swadi Zghair F, Alrufaie MM.   +8 more
europepmc   +4 more sources

Interleukin-39 aggravates sepsis by inducing self-sustaining neutrophil activation in the lungs via the CXCL1-CXCR2 pathway. [PDF]

Int J Biol Sci
Zhang J, Liu J, Wang Y, Xu Y, Rodrigues RM, Zhou Z, Lu J, Li Z, Wang X, Li J, He Y, Lafdil F, Mo R, Mao E, Xie Q, Xiang X.   +15 more
europepmc   +2 more sources

Interleukin -39 Expression in Pleural Effusion and Its Diagnostic Value for Tuberculous Pleurisy. [PDF]

J Inflamm Res
This study aimed to assess Interleukin-39 (IL-39) levels in various types of pleural effusion (PE), explore IL-39's diagnostic value in tuberculous pleurisy, analyze its correlation with other PE and tuberculosis indicators, and confirm the involvement of IL-39 in tuberculosis infection and the resulting inflammatory response.This study enrolled 113 ...
Song X, Zhang Q, Cen T, Fan W, Chen W, Guo L, Du Y, Lv C, Tang P, Dong Z, Li M, Ding Q.   +11 more
europepmc   +5 more sources

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

Biomedicine, 2022
Introduction and Aim: The pro-inflammatory cytokine IL-39, a member of the IL-12 family plays a key role in the inflammatory response by modulating immune cell activity and inflammation. A literature search shows no study undertaken for the effect of IL-39's on arthritis so far.
null Wafaa Tialp Mohammed, null Mohammed Hadi Munshed Alosami, null Alia Essam Mahmood Alubadi   +2 more
openaire   +1 more source

Interleukin-23 receptor signaling by interleukin-39 potentiates T cell pathogenicity in acute graft-versus-host disease

American Journal of Transplantation, 2021
IL-12 (p35/p40) and IL-23 (p19/p40) signal through IL-12R (IL-12Rβ2/β1) and IL-23R (IL-23Rα/IL-12Rβ1), respectively, which can promote pathogenic T lymphocyte activation, differentiation, and function in graft-versus-host disease (GVHD). With the use of murine models of allogeneic hematopoietic cell transplantation (HCT), we found that IL-12Rβ1 on ...
David Bastian, Xiaohui Sui, Hung Dang Nguyen, Yongxia Wu, Steven Schutt, Linlu Tian, Mohammed Hanief Sofi, Yuejun Liu, Paul Martin, Eric Bartee, Xue-Zhong Yu   +10 more
openaire   +2 more sources

Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism

Brazilian Journal of Infectious Diseases, 2018
Aim: To analyze the influence of the –31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods: Functional dyspepsia was diagnosed according to the Rome III criteria.
Tássia Flores Rech, Luiz Edmundo Mazzoleni, Felipe Mazzoleni, Carlos Fernando de Magalhães Francesconi, Guilherme Becker Sander, Rafael Tomoya Michita, Débora Dreher Nabinger, Tobias Cancian Milbradt, Ronaldo João Spinato Torresini, Daniel Simon   +9 more
doaj   +3 more sources