Results 21 to 30 of about 417,692 (230)

Matrix metalloproteinase-9 is elevated and related to interleukin-17 and psychological stress in male infertility: A cross-sectional study

International Journal of Reproductive BioMedicine, 2021
Background: Matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17) and psychological stress are known to play a role in the pathogenesis of male infertility.
Ann Prasad Mary, Hanumanthappa Nandeesha, Dasari Papa, Thyagaraju Chitra, Rajesh Nachiappa Ganesh, Vikas Menon   +5 more
doaj   +1 more source

The complicated use of dupilumab in the treatment of atypical generalized pemphigus erythematosus: A report of two cases

Human Vaccines & Immunotherapeutics, 2023
Pemphigus is a rare autoimmune disease and has the potential to be fatal without treatment. Pemphigus erythematosus (PE) is a benign type of pemphigus foliaceus. Glucocorticoids and immunosuppressive agents are primary therapeutic modalities in pemphigus
Jie Chen, Siji Chen, Xia Wu, Xiaoyun Jiang, Yongdong Wang, Hao Cheng   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats

Acta Biomedica Scientifica, 2016
The article presents the pathophysiological assessment of the results of atherogenic dyslipidemia simulation in Wistar rats. Dyslipidemia was followed by 24 % increase of triglyceride and 19 % raise of total cholesterol in blood, while the atherogenic ...
V. G. Banzaraksheev
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Novel Insights Into The Role Of Serum Interleukin-39 In Patients With Systemic Lupus Erythematosus

Iraqi Journal of Science
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that has a genetic predisposition and a complex pathogenesis in which the involvement of various cytokines has been shown. In the current study, serum interleukin-39 (IL-39) levels from 99 patients with SLE and 33 healthy control subjects who attended the Baghdad Teaching Hospital ...
Amal Mahdi Al Rubaye, Inas K. Sharquie, Faiq I. Gorial   +2 more
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dramatic secukinumab-mediated improvements in refractory leprosy-related neuritis via the modulation of T helper 1 (Th1) and T helper 17 (Th17) immune pathways

Revista da Sociedade Brasileira de Medicina Tropical, 2021
A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the ...
Patrícia Shu Kurizky, Jorgeth de Oliveira Carneiro da Motta, Natanael Victor Furtunato Bezerra, Marcia Carolline dos Santos Sousa, Danilo Corazza, Taiana Karla dos Santos Borges, Ciro Martins Gomes   +6 more
doaj   +1 more source

Levels of Interleukin-39, C–Reactive Protein in Patient's Serum with H. Pylori Infections

Saudi Journal of Medicine
The study was carried out to detection of H.pylori in (200) patients who attended two teaching hospitals in Baghdad. The diagnosis done by Immunochromatography methods. Stools and blood samples was taken from each patient as well as other (30) healthy control matching in their age.
Khalil Ismail Abid Mohammed, Ameen Abdul Hasan AL-Alwany, Sarmad M. Zeiny, Saad Hasan Mohammed Ali, Wifaq M. Ali, Suha A. AL-Fakhar, Jinan M. Mousa   +6 more
openaire   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source