Results 31 to 40 of about 417,692 (230)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Hyperoxia Exacerbates Postnatal Inflammation-Induced Lung Injury in Neonatal BRP-39 Null Mutant Mice Promoting the M1 Macrophage Phenotype

Mediators of Inflammation, 2013
Rationale. Hyperoxia exposure to developing lungs—critical in the pathogenesis of bronchopulmonary dysplasia—may augment lung inflammation by inhibiting anti-inflammatory mediators in alveolar macrophages. Objective. We sought to determine the O2-induced
Mansoor A. Syed, Vineet Bhandari
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

the Study of some pro- inflammatory and Anti –inflammatory interleukins in diabetic patients

Academic Science Journal
Objective; The objective  of present   research is evaluation roles of IL-38 and IL-39  indicators in pathophysiology  of diabetic mellitus type II. Methods; The conducted investigation  was occurred inside Bagdad capital during time  period   1/8 to
enaas saad, Dhuha Adnan, Mohammed Alwan   +2 more
doaj   +1 more source

Cholinergic Urticaria, an Effective and Safe “Off Label” Use of Dupilumab: A Case Report with Literature Review

Clinical, Cosmetic and Investigational Dermatology, 2022
Maria Maddalena Sirufo,1,2 Alessandra Catalogna,1,2 Martina Raggiunti,1,2 Francesca De Pietro,1,2 Lia Ginaldi,1,2 Massimo De Martinis1,2 1Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy; 2Allergology and ...
Sirufo MM, Catalogna A, Raggiunti M, De Pietro F, Ginaldi L, De Martinis M   +5 more
doaj  

Interleukin-39 as a Potential Biomarker of Diabetic Neuropathy: A Case–Control Study with ROC Curve Analysis

Chemical Interactions
Background: Diabetic neuropathy is considered the most common prevalent microvascular complication of type 2 diabetes mellitus, manifested by progressive nerve destruction resulting from metabolic and inflammatory mechanisms. The role of IL-39 as a novel pro-inflammatory mediator in diabetic neuropathy has not been clarified yet.
Hasan R. Hamood, Hanan R. Hamoud, Fatima Ghazi Talab Al-Tamimi, Hanaa Addai Ali   +3 more
openaire   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Targeting p19 as a treatment option for psoriasis: an evidence-based review of guselkumab

Therapeutics and Clinical Risk Management, 2018
Todd Wechter,1 Abigail Cline,2 Steven R Feldman2–4 1Stony Brook Medicine, Stony Brook, NY, USA; 2Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Pathology, Wake ...
Wechter T, Cline A, Feldman SR
doaj