Results 111 to 120 of about 14,230,992 (393)

The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo

Frontiers in Immunology, 2018
Interleukin (IL)-4 plays a central role in determining the phenotype of naïve CD4+ T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to date,
Tomohiro Yoshimoto, Tomohiro Yoshimoto
doaj   +1 more source

γδ T cells affect IL-4 production and B-cell tolerance [PDF]

, 2014
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun, Cohen, Finkelman, Gerber, Greg A. Kirchenbaum, Hidaka, Hirose, Hua Huang, Izui, John C. Cambier, Koichi Ikuta, Kubo, Lawrence J. Wysocki, M. Kemal Aydintug, Rebecca L. O’Brien, Ryan A. Heiser, Simon R. Carding, Sperling, Sunaga, Tamara L. Casper, Thiago O. Detanico, Willi K. Born, Yafei Huang   +22 more
core   +1 more source

Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines*

Journal of Biological Chemistry, 2013
Background: Dual neutralization of IL-4 and IL-13 is a promising therapeutic approach for asthma and allergy. Results: Knobs-into-holes IgG1 and IgG4 bispecific antibodies targeting both cytokines were developed. Conclusion: Bispecific antibodies of both
Christoph Spiessa, Jack Bevers, Janet Jackmanb, Nancy Chianga, Gerald Nakamuraa, chael Dillona, Hongbin Liuc, Patricia Molinac, J. M. Elliottd, Whitney Shatzd, M. Justin, Scheerd, Glen Giesee, Josefine Perssone, Z. Yin, Mark S. Dennisa, James Giulianottif, Prateek, Guptaf, Dorothea Reillyf, Enzo Palmag, Jianyong Wangh, Eric Stefanichg, Heleen Scheerensi, Germaine Fuha, Lawren C. Wub   +25 more
semanticscholar   +1 more source

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang, Shuang Liu, Jiale Wang, Kaiyang Xue, Shenwei Li, Zhongheng Du   +5 more
wiley   +1 more source

Evaluation of the levels of interleukins IL-4, IL-13, IL-5, IL-10 and IL-33 in atopic dermatitis patients with and without dupilumab therapy

Frontiers in Immunology
BackgroundInterleukins IL-4, Il-5, IL-10, IL-13 and IL-33 play an important role in atopic dermatitis patients. The aim of our study is to address several knowledge gaps in the understanding of interleukin dynamics in atopic dermatitis patients and the ...
Jarmila Čelakovská, Eva Čermáková, Petra Boudková, Jan Krejsek   +3 more
doaj   +1 more source

The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis

Turkish Archives of Otorhinolaryngology, 2015
Objective:With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and ...
Erol Keleş, Şule Özkara, Nevin İlhan, Hilal Güngör, Turgut Karlıdağ, Şinasi Yalçın   +5 more
doaj   +1 more source

Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis

Medicina, 2019
Background and Objectives: Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the
Hamid Reza Mozaffari, Maryam Molavi, Pia Lopez-Jornet, Masoud Sadeghi, Mohsen Safaei, Mohammad Moslem Imani, Roohollah Sharifi, Hedaiat Moradpoor, Amin Golshah, Ladan Jamshidy   +9 more
doaj   +1 more source

Interleukin-4: A Cytokine to Remember

Journal of Immunology, 2012
IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning.
Sachin P. Gadani, James C. Cronk, Geoffrey T Norris, J. Kipnis   +3 more
semanticscholar   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Oral administration of Lactiplantibacillus plantarum GKK1 ameliorates atopic dermatitis in a mouse model

Frontiers in Microbiology
Background/objectivesAtopic dermatitis (AD) is a prevalent chronic skin condition, especially in young children, with rising incidence in developed countries. AD causes repeated scratching, and thus affecting quality of life.
Tzu-Chun Lin, Yu-Chieh Wu, You-Shan Tsai, Shih-Wei Lin, Chin-Chu Chen, Chin-Chu Chen, Chin-Chu Chen, Ming-Ju Chen, Ming-Ju Chen, Yen-Po Chen, Yen-Po Chen   +10 more
doaj   +1 more source