Results 201 to 210 of about 14,230,992 (393)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Sustained Transcriptional Response to Lipopolysaccharide and Interleukin-4 in an Immortalized Mouse Microglial Cell Line. [PDF]

Mol Neurobiol
Herrero-González A, Puente-Sanz A, Pérez-Rodríguez D, Anuncibay-Soto B, Letek M, Regueiro-Purriños M, Fernández-López A.   +6 more
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Contents of interleukins-4 and 6 in the serum of blood of children with bronchial asthma, dependence on the severity and level of the control of the diseases [PDF]

, 2018
V.М. Dudnyk, O.V. Kutsak
openalex   +1 more source

Supplementary Figure 4 from GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-α

, 2023
Gary Kohanbash, Kayla McKaveney, Masashi Sakaki, Ryo Ueda, Arlan Mintz, Nduka Amankulor, Mitsugu Fujita, John R. Ohlfest, Hideho Okada   +8 more
openalex   +1 more source

Study on the correlation between Interleukin 4 and febrile seizures. [PDF]

Cytojournal
Xiang X, Wang S, Tang C, Jin H, Lei L, Mao G, Huang X, Huang B.   +7 more
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Supplementary Figure 4 from A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer

, 2023
Louisa S. Chard, Eleni Maniati, Pengju Wang, Zhongxian Zhang, Dongling Gao, Jiwei Wang, Fengyu Cao, Jahangir Ahmed, Margueritte El Khouri, Jonathan Hughes, Shengdian Wang, Xiaozhu Li, Béla Dénes, István Fodor, Thorsten Hagemann, Nicholas R. Lemoine, Yaohe Wang   +16 more
openalex   +1 more source

Disentangling depression in women with diabetes: evidence for measure-dependent associations with interleukin-4 and common inflammatory biomarkers. [PDF]

Front Psychiatry
Perez NB, Gordillo Sierra P, Finik J, Fletcher J, Hanna DB, Sharma A, Anastos K, Rubin LH, Melkus GD, Aouizerat B.   +9 more
europepmc   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source