Results 211 to 220 of about 14,230,992 (393)

Data from Expression of Interleukin-4 Receptor Alpha in Human Pleural Mesothelioma Is Associated with Poor Survival and Promotion of Tumor Inflammation

, 2023
Bryan M. Burt, Andrew Bader, Daniel Winter, Scott J. Rodig, Raphael Bueno, David J. Sugarbaker   +5 more
openalex   +1 more source

Interleukine-4 [PDF]

médecine/sciences, 1990
openaire   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation.

Immunity, 2014
Y. Motomura, H. Morita, K. Moro, S. Nakae, D. Artis, T. Endo, Yoko Kuroki, O. Ohara, S. Koyasu, M. Kubo   +9 more
semanticscholar   +1 more source

Erratum to "Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization". [PDF]

Research (Wash D C)
Lv H, Wang Y, Tan L, Xie Y, Liu P, Guan M, Cong J, Xu Y.   +7 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

p38 Mitogen-activated Protein Kinase Regulates Interleukin-4-induced Gene Expression by Stimulating STAT6-mediated Transcription [PDF]

, 2002
Marko Pesu, Saara Aittomäki, Kati Takaluoma, Anssi Lagerstedt, Olli Silvennoinen   +4 more
openalex   +1 more source

Neurons differentially upregulate type 2 immune cytokines and interleukin-4 receptor subtypes during neuroinflammation. [PDF]

Acta Neuropathol Commun
Domingues M, Gärtner Y, Hanuscheck N, Schmaul S, Zipp F, Vogelaar CF.   +5 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

A Novel Polymorphism in the Promoter Region of the Interleukin-4 Gene and Association with Type 1 Diabetes Mellitus

, 2003
智子 大久保, Tomoko Ohkubo
openalex   +1 more source