Interleukin-4 protects retinal ganglion cells and promotes axon regeneration. [PDF]
Zuo Z +5 more
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Expanding the potential of monoclonal antibodies against interleukin-4 and interleukin-13 in genodermatoses: A case series on the efficacy and safety of dupilumab in epidermolysis bullosa and ichthyosis. [PDF]
Caroppo F +4 more
europepmc +1 more source
Association between 25-hydroxy vitamin D, interleukin-4, and interferon-γ levels and asthma in children with Mycoplasma pneumonia infection. [PDF]
Shen T, Liu T, Kong L, Li Y.
europepmc +1 more source
Mineral coated microparticles delivering Interleukin-4, Interleukin-10, and Interleukin-13 reduce inflammation and improve function after spinal cord injury in a rat. [PDF]
Hellenbrand DJ +13 more
europepmc +1 more source
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Since its discovery in 1982, numerous biological activities of interleukin-4 (IL-4) have been described. Like other cytokines, IL-4 is highly pleiotropic, both with respect to the number of different target cells that are responsive to it and with respect to the number of different biological responses it elicits.
J H, Jansen +3 more
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Summary: Experimental infection of mice with Listeria monocytogenes (L. monocytogenes) has served as an appropriate model for analyzing Thl nil driven immune responses. Generally, Th2 responses are absent and IL‐4 is not detectable. Here, we describe experimental settings under which IL‐4 is detectable in listeriosis.
Kaufmann, S. +4 more
openaire +3 more sources
Interleukin‐4 and the interleukin‐4 receptor in allergic contact dermatitis
Contact Dermatitis, 1998Cutaneous immune responses involving T helper (TH) type 1 (TH1) and type 2 (TH2) T cells, characterised by secretion of interferon‐γ (Ifn‐γ) and interleukin‐4 (IL‐4), respectively, have both been reported in allergic contact dermatitis (ACD). We used immunohistochemistry to localize expression of IL‐4 in ACD lesions and unaffected skin.
A, Rowe, C B, Bunker
openaire +2 more sources
Interleukin-4 as a therapeutic target
Pharmacology & Therapeutics, 2023Interleukin-4 (IL-4) is a pleiotropic cytokine mainly known for its role in type 2 immunity. Therapies antagonizing or blocking IL-4 activity have been developed to counteract diseases such as atopic dermatitis and asthma. In contrast, other disorders experimentally benefit from IL-4-related effects and IL-4 recently demonstrated beneficial activity in
Yvonne, Gärtner +3 more
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Role of interleukin-4 in atherosclerosis
Archives of Pharmacal Research, 2006Vascular endothelial cell injury or dysfunction has been implicated in the onset and progression of cardiovascular diseases including atherosclerosis. A number of previous studies have demonstrated that the pro-oxidative and pro-inflammatory pathways within vascular endothelium play an important role in the initiation and progression of atherosclerosis.
Yong Woo, Lee, Anjali A, Hirani
openaire +2 more sources

