Results 51 to 60 of about 705,101 (300)

Treadmill Exercise Attenuates Cerebral Ischemia–Reperfusion Injury by Promoting Activation of M2 Microglia via Upregulation of Interleukin-4

Frontiers in Cardiovascular Medicine, 2021
Background: Exercise has been proven to be an effective therapy for stroke by reducing the microglia-initiated proinflammatory response. Few studies, however, have focused on the phenotypic changes in microglia cells caused by exercise training.
Juanjuan Lu, Juanjuan Lu, Jie Wang, Long Yu, Rong Cui, Rong Cui, Ying Zhang, Hanqing Ding, Guofeng Yan   +8 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Correlation between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgical trauma [PDF]

Саратовский научно-медицинский журнал, 2013
Aim: to evaluate the correlations between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgery. Material and methods.
Korsakov I.N., Voskanyan S.E., Naydenov E.V., Timashkov D.A., Chervov A.Yu., Volkov A.A., Bolshakov M.S.   +6 more
doaj  

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. [PDF]

, 1996
Reversible airway hyperreactivity underlies the pathophysiology of asthma, yet the precise mediators of the response remain unclear. Human studies have correlated aberrant activation of T helper (Th) 2-like effector systems in the airways with disease. A
Corry, DB, Erle, DJ, Folkesson, HG, Locksley, RM, Matthay, MA, Warnock, ML, Wiener-Kronish, JP   +6 more
core  

Granulocyte-activating mediators (GRAM) [PDF]

, 1988
In the present study we investigated the capability of human epidermal cells to generate granulocyte-activating mediators (GRAM). It could be shown that human epidermal cells as well as an epidermoid carcinoma cell line (A431) produce an epidermal cell ...
Kapp, A., Möller, A., Putz, Reinhard, Zeck-Kapp, G.   +3 more
core   +1 more source

History of interleukin-4 [PDF]

Cytokine, 2015
The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly. Illustrative is the extended time from the first report of IL-4 in 1982 to the establishment of the efficacy ...
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Interleukin‐4 can induce interleukin‐4 production in dendritic cells

Immunology, 2005
SummaryThe presence of interleukin‐4 (IL‐4) during the generation of dendritic cells (DC) from precursor cells results in measurable increases of IL‐12 in supernatants but IL‐4 secretion has not been reported. However, DC have IL‐4 receptors and are able to make IL‐4. We therefore sought evidence for autocrine effects of IL‐4 on DC.
Asher, Maroof, Michelle, Penny, Rosetta, Kingston, Clare, Murray, Sabita, Islam, Penelope A, Bedford, Stella C, Knight   +6 more
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

Frontiers in Immunology, 2018
Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells.
Ilkka S. Junttila, Ilkka S. Junttila
doaj   +1 more source