Results 101 to 110 of about 14,492,078 (303)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

overexpression enhances saturated fatty acid–induced inflammatory cytokine gene expression in sheep

European Journal of Inflammation, 2018
Saturated fatty acids (SFAs) can directly stimulate innate immune responses, thereby exacerbating inflammatory aspects of metabolic syndrome. Dietary SFAs act as ligands of Toll-like receptor 4 (TLR4), triggering associated signaling pathways.
Xue Xu, Mei-Yu Qi, Shuang Liu, Xu-Ting Song, Jia-Nan Zhang, Yu-Fei Zhai, Ming-Hai Lu, Hong-Bing Han, Zheng-Xing Lian, Yu-Chang Yao   +9 more
doaj   +1 more source

Interleukin-4 receptor alpha signaling regulates monocyte homeostasis. [PDF]

FASEB J, 2022
Haider P, Kral-Pointner JB, Salzmann M, Moik F, Bleichert S, Schrottmaier WC, Kaun C, Brekalo M, Fischer MB, Speidl WS, Hengstenberg C, Podesser BK, Huber K, Pabinger I, Knapp S, Brombacher F, Brostjan C, Ay C, Wojta J, Hohensinner PJ.   +19 more
europepmc   +1 more source

Efeito inibitório da interleucina-4 e interleucina-13 sobre a hiperalgesia inflamatória [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.O presente estudo utilizou um modelo de hiperalgesia mecânica (teste de Randall-Selitto modificado) para investigar os efeitos da interleucina(IL)-4 e IL-13 ...
Veiga, Fabiane Hiratsuka
core  

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Association of Interleukin-4 Receptor Gene Polymorphism with Chronic Periodontitis

پزشکی بالینی ابن سینا, 2011
Introduction & Objective: Periodontitis is a multifactorial disease in which host immune system and genetic factors have an important role in its pathogenesis. Genetic polymorphisms in cytokines and their receptors have been proposed as potential markers
Masoomeh Khoshhal, Janet Moradi Haghgoo, Parviz Torkzaban, Seyyed Reza Arabi, Fariborz Vafaee, Mehrdad Hajiloie, Banafsheh Pourmoradi   +6 more
doaj  

Rocaglamide Suppresses Allergic Reactions by Regulating IL-4 Receptor Signaling

Molecules
Rocaglamide (Roc-A), a natural phytochemical isolated from Aglaia species, is known to exert anticancer effects. Allergic inflammation can enhance the tumorigenic potential of cancer cells. We hypothesized that Roc-A could regulate allergic inflammation.
Hyein Jo, Misun Kim, Jaewhoon Jeoung, Wonho Kim, Yoon Ho Park, Hyun Suk Jung, Wook Lee, Dooil Jeoung   +7 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Trem2 acts as a non‐classical receptor of interleukin‐4 to promote diabetic wound healing

Clinical and Translational Medicine
Background The immunoglobulin superfamily protein Trem2 (triggering receptor expressed on myeloid cells 2) is primarily expressed on myeloid cells where it functions to regulate macrophage‐related immune response induction.
Xinlin Zhu, Chao Zhang, Weiwei Jiang, Zhaoxiang Zeng, Keming Zhang, Mingwei Du, Juan Chen, Qian Wu, Wanqing Liao, Youming Chen, Wenjie Fang, Weihua Pan   +11 more
doaj   +1 more source

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes:the MRC-ILA Heart Study [PDF]

, 2014
AIMS: Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation.
Greenwood, J.P., Hall, Alistair S., Rothman, A.M.K., Morton, Allison C., Foley, C., Chase, A., Greenwood, John P, Chase, Alex, Morton, Allison C, Wang, Duolao, Rothman, Alexander M K, Banya, Winston, Clarke, B., Gunn, J., Crossman, David C, Rothman, Alexander M. K., Crossman, David C., Flather, Marcus D, Rothman, Alexander M.K., Clarke, Bernard, Fox, Keith, Fox, K., Banya, W., Hall, Alistair S, Gunn, Julian, Flather, Marcus D., Greenwood, John P., Foley, Claire, Hall, A.S., Morton, A.C.   +29 more
core   +1 more source