Results 81 to 90 of about 14,492,078 (303)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4) [PDF]

, 2012
Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh
Robben, Joris, Cooke, Alexandra, Gould, Gwyn W., McIntosh, Kathryn A., Gould, Gwyn, Milligan, Graeme, Cunningham, Margaret Rose, Pediani, John D., Cooke, Alexandra E., McIntosh, Kathryn, Nilsson, Mary, Mundell, Stuart, Plevin, Robin, Cunningham, Margaret R., McIntosh, Kathryn A, Pediani, John D, Gould, Gwyn W, Pediani, John, Nilsson, Mary Francis, Cunningham, Margaret R, Cooke, Alexandra E   +20 more
core   +2 more sources

Inhibition of Toll-like receptor 4 and Interleukin-1 receptor prevent SARS-CoV-2 mediated kidney injury

Cell Death Discovery, 2023
Acute kidney injury (AKI) is a common and severe complication of the coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly affects the glomerular and tubular epithelial cells to induce AKI; however ...
Daigo Nakazawa, Yohei Takeda, Masatoshi Kanda, Utano Tomaru, Haruko Ogawa, Takashi Kudo, Satoka Shiratori-Aso, Kanako Watanabe-Kusunoki, Yusho Ueda, Atsuko Miyoshi, Fumihiko Hattanda, Saori Nishio, Ryo Uozumi, Akihiro Ishizu, Tatsuya Atsumi   +14 more
doaj   +1 more source

SUPERSEDED - Supplementary Figures: Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence

, 2019
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2626 ## Supplementary Figures from the manuscript "Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti ...
McCulloch, Laura
core   +1 more source

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells [PDF]

, 2008
Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery.
Bodnár, Andrea, Garcia Parajo, M.F., van Dijk, E.M.H.P., Jenei, Attila, Andrea Bodnár, Thomas A. Waldmann, Garcia-Parajo, Maria F., Hulst, Niek F., van, Sándor Damjanovich, Attila Jenei, Bakker, B. I. de, van Hulst, N.F., Damjanovich, Sándor, Dóczy-Bodnár, Andrea, György Vámosi, Dijk, Erik M. H. P., van, Waldmann, Thomas A., María F. Garcia-Parajo, Niek F. van Hulst, de Bakker, Bärbel I., Vámosi, György, Erik M. H. P. van Dijk, Dijk, E. M. H. P. van, de Bakker, B.I., Bärbel I. de Bakker   +24 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Characterization of a gp130 Signaling Receptor Polymorphism [PDF]

, 2013
We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core  

Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]

, 2008
During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core   +1 more source