Results 71 to 80 of about 14,492,078 (303)

IL-4Rα Polymorphism Is Associated With Myasthenia Gravis in Chinese Han Population

Frontiers in Neurology, 2018
Interleukin-4 (IL-4) is a potent growth and differentiation factor for B cells which play a vital role in the pathogenesis of myasthenia gravis (MG). IL-4 exerts its function by binding to three types of IL-4 receptor (IL-4R) complexes. IL-4Rα is the key
Ping Jiang, Yao-Xian Yue, Yu Hong, Yanchen Xie, Xiang Gao, Chuan-Kai Gu, Hong-Jun Hao, Yue Qin, Xiao-Jun Ding, Min Song, Hai-Feng Li, Xu Zhang   +11 more
doaj   +1 more source

Priming by recombinant chicken interleukin-2 induces selective expression of IL-8 and IL-18 mRNA in chicken heterophils during receptor-mediated phagocytosis of opsonized and nonopsonized Salmonella enterica serovar enteritidis [PDF]

, 2003
Heterophils, the principal avian polymorphonuclear leukocytes (PMNs) equivalent to the mammalian neutrophil, function as professional phagocytes against bacterial infections, mediate acute inflammation, and respond to cytokine stimulation to aid in ...
Michael H Kogut, Pete Kaiser, Kogut, Michael H, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Toll-Like Receptor 4, 2, and Interleukin 1 Receptor Associated Kinase4: Possible Diagnostic Biomarkers in Myelodysplastic Syndrome Patients

Advanced Biomedical Research
Background: Myelodysplastic syndrome (MDS) is a clonal hematologic disorder that requires the integration of morphologic, cytogenetic, hematologic, and clinical findings for a successful diagnosis.
Parvin Khalilian, Nahid Eskandari, Mohammad Jafar Sharifi, Mohammad Soltani, Pardis Nematollahi   +4 more
doaj   +1 more source

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia [PDF]

, 2012
<b>Objective—</b><p></p> The p75 neurotrophin receptor (p75^NTR) contributes to diabetes mellitus−induced defective postischemic neovascularization.
Spinetti, Gaia, Ambra Gotti, Losa, Sergio, Christa Noehammer, Ezio Faglia, Orazio Fortunato, Caporali, Andrea, Emanueli, Costanza, Nailor, Audrey, Cardinali, Alessandro Cardinali, Alessandro Cardinali, Manuela Hofner, Noehammer, Christa, Sergio Losa, Gotti, Ambra, Miller, Ashley M, Vierlinger, Klemens, Fortunato, Orazio, Ashley M. Miller, Tijana Mitić, Costanza Emanueli, Miller, Ashley M., Hofner, Manuela, Caporali, Andrea; id_orcid, Cardinali, Alessandro, Meloni, Marco, Paolo Madeddu, Gaia Spinetti, Faglia, Ezio, Klemens Vierlinger, Audrey Nailor, Mitić, Tijana, Andrea Caporali, Madeddu, Paolo, Marco Meloni   +34 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Association of Severe Respiratory Syncytial Virus Bronchiolitis with Interleukin‐4 and Interleukin‐4 Receptor α Polymorphisms [PDF]

The Journal of Infectious Diseases, 2003
The association of variants of genes encoding interleukin (IL)-4 and the IL-4 receptor alpha chain (IL-4Ralpha) with respiratory syncytial virus (RSV) bronchiolitis was examined in hospitalized infants. Polymorphisms in IL-4 (C-590T) and IL-4Ralpha (I50V and Q551R) were genotyped by restriction fragment-length polymorphism analysis.
Hoebee, B, Rietveld, E (Edwin), de Bont, L (Louis), van Oosten, M, Hodemaekers, HM, Auvinen, Anssi-Pekka, Neijens, HJ (Herman), Kimpen, JLL, Kimman, TG   +8 more
openaire   +2 more sources

Modulation of human immune responses by bovine interleukin-10 [PDF]

, 2011
Cytokines can be functionally active across species barriers. Bovine IL-10 has an amino acid sequence identity with human IL-10 of 76.8%. Therefore, the aim of this study was to evaluate whether bovine IL-10 has immunomodulatory activities on human ...
Schoemaker, R., de Ruiter, T., Weg-Schrijver, Elise, van de, Westphal Adrie H., Tijhaar, E., Savelkoul, H.F.J., Adrie H Westphal, Westphal, A.H., Savelkoul Huub F. J., R J Joost van Neerven, Edwin Tijhaar, Neerven, R.J.J., van, Gerco den Hartog, van de Weg-Schrijver Elise, Schoemaker Ruud, den Hartog Gerco, den Hartog, C.G., Huub F J Savelkoul, van de Weg-Schrijver, Elise, Talitha de Ruiter, Elise van de Weg-Schrijver, de Ruiter Talitha, Ruiter, T., de, Ruud Schoemaker, van Neerven, R.J.J., Hartog, C.G., den, Tijhaar Edwin, van Neerven R. J. Joost   +27 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Frontiers in Immunology, 2019
Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines.
Yi Wang, Hua Jiang, Hong Luo, Yansha Sun, Bizhi Shi, Ruixin Sun, Zonghai Li, Zonghai Li   +7 more
doaj   +1 more source