Results 151 to 160 of about 719,716 (198)
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Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy
Clinical Science, 1999Minimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy.
Gillespie, KM +4 more
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Interleukin‐4 and the interleukin‐4 receptor in allergic contact dermatitis
Contact Dermatitis, 1998Cutaneous immune responses involving T helper (TH) type 1 (TH1) and type 2 (TH2) T cells, characterised by secretion of interferon‐γ (Ifn‐γ) and interleukin‐4 (IL‐4), respectively, have both been reported in allergic contact dermatitis (ACD). We used immunohistochemistry to localize expression of IL‐4 in ACD lesions and unaffected skin.
A, Rowe, C B, Bunker
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The rat interleukin 4 receptor: coevolution of ligand and receptor
Cytokine, 1995A rat interleukin 4 receptor (IL-4R) cDNA was cloned by polymerase chain reaction (PCR) using RNA of Con A activated T cells and primers deduced from mouse and human IL-4R sequences. Sequence analysis revealed an open reading frame for a putative membrane protein of 800 amino acids in length.
G, Richter +3 more
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The interleukin-4 receptor: signal transduction by a hematopoietin receptor
Journal of Leukocyte Biology, 1994Abstract Over the last several years, the receptors for numerous cytokines have been molecularly characterized. Analysis of their amino acid sequences shows that some of these receptors bear certain motifs in their extracellular domains that define a family of receptors called the Hematopoietin receptor superfamily [1–3].
A D, Keegan, J H, Pierce
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Interleukin 4, interleukin 4 receptor‐α and interleukin 10 gene polymorphisms in Chagas disease
Parasite Immunology, 2011SummaryIn this study, we investigated the association between single‐nucleotide polymorphisms (SNPs) of the interleukin‐4 (IL4), interleukin‐4 receptor‐α (IL4RA) and interleukin‐10 (IL10) genes with the development of chagasic heart disease. This study included 260 patients from Colombia who were serologically positive for Trypanosoma cruzi antigens ...
O, Flórez, J, Martín, C I, González
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Interleukin-4 receptors on human blood mononuclear cells
Cellular Immunology, 1990We have studied regulation of the expression of the interleukin-4 receptor (IL-4R) on human blood mononuclear cells (PBMC) using both 125I-IL-4 binding assay and flow cytometric analysis of biotinylated IL-4 (B-IL-4) binding. PBMC express approximately 300 high-affinity IL-4R per cell (Kd = 25-100 pM).
C E, Zuber +4 more
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Interleukin-4 andInterleukin-4 Receptor AlphaGene Polymorphisms in Recurrent Aphthous Stomatitis
Immunological Investigations, 2018Recurrent aphthous stomatitis (RAS) is a common oral condition with a major impact on the quality of life. The condition is thought to be due to the overexpression of T helper-1(Th1)-related cytokines. Since interleukin-4 (IL-4) and its receptor (IL-4Rα) are antagonistic to Th-1 pathways, polymorphisms in their genes may also be involved in the ...
Shamsolmoulouk Najafi +6 more
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Journal of Urology, 2002
Interstitial cystitis is a chronic and sterile inflammatory disease of the bladder. Clinically many patients with interstitial cystitis also have allergic or autoimmune diseases. Recent studies have suggested that allelic variations in the adrenergic receptor beta2 gene, the interleukin (IL)-4 gene and its receptor gene are closely associated with ...
Kimio, Sugaya +5 more
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Interstitial cystitis is a chronic and sterile inflammatory disease of the bladder. Clinically many patients with interstitial cystitis also have allergic or autoimmune diseases. Recent studies have suggested that allelic variations in the adrenergic receptor beta2 gene, the interleukin (IL)-4 gene and its receptor gene are closely associated with ...
Kimio, Sugaya +5 more
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1995
Abstract Both the murine (Mosley et al. 1989) and human (ldzerda et al. 1990) IL-4 receptors have been molecularly cloned. The murine IL-4 receptor, which was cloned first (Mosley et al. 1989), is produced as an 810-amino-acid precursor with a predicted 25-amino-acid signal peptide (GenBank accession number M27959).
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Abstract Both the murine (Mosley et al. 1989) and human (ldzerda et al. 1990) IL-4 receptors have been molecularly cloned. The murine IL-4 receptor, which was cloned first (Mosley et al. 1989), is produced as an 810-amino-acid precursor with a predicted 25-amino-acid signal peptide (GenBank accession number M27959).
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Immunological Investigations, 2013
The aim of this study was to determine whether the functional interleukin-4 (IL-4) -590 C/T, IL-4 receptor (IL-4R) 1902 G/A, IL-18 -607 C/A, and -137 G/C polymorphisms polymorphisms confer susceptibility to rheumatoid arthritis (RA).Meta-analysis was conducted on the associations between these IL-4, IL-4R, and IL-18 polymorphisms and RA.A total of 12 ...
Gwan Gyu, Song +3 more
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The aim of this study was to determine whether the functional interleukin-4 (IL-4) -590 C/T, IL-4 receptor (IL-4R) 1902 G/A, IL-18 -607 C/A, and -137 G/C polymorphisms polymorphisms confer susceptibility to rheumatoid arthritis (RA).Meta-analysis was conducted on the associations between these IL-4, IL-4R, and IL-18 polymorphisms and RA.A total of 12 ...
Gwan Gyu, Song +3 more
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