Results 101 to 110 of about 382,334 (303)

Radiation-Induced Interleukin-6 Expression through Mapk/P38/Nf-Kappa B Signaling Pathway and the Resultant Antiapoptotic Effect on Endothelial Cells through Mcl-1 Expression with Sil6-R Alpha

, 2010
To investigate the mechanism of interleukin-6 (IL-6) activity induced by ionizing radiation. Methods and Materials: Human umbilical vascular endothelial cells ( RUVECs) were irradiated with different doses to induce IL-6.
周佳宏;陳思原;成佳憲, CHOU, CHIA-HUNG;CHEN, SHEE-UAN;CHENG, JASON CHIA-HSIEN   +1 more
core  

Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo

, 2013
Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents.
Eva Juengel, Jasmina Makarević, Axel Haferkamp, Georg Bartsch, Roman A Blaheta, Jüngel, Eva, Nelson, Karen, Blaheta, Roman A., Igor Tsaur, Makarević, Jasmina, Karen Nelson, Tsaur, Igor, Haferkamp, Axel, Bartsch, Georg   +13 more
core   +1 more source

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Correlation of the levels of inflammatory factors and miRNAs in blood with the clinical stage of lo-wer extremity atherosclerotic occlusive disease in elderly patients [PDF]

精准医学杂志
Objective To investigate the correlation of interleukin (IL)-6, interleukin-8 (IL-8), tissue inhibitor of me-talloproteinase-1 (TIMP-1), miRNA-128, and miRNA-381 with the clinical stage of lower extremity atherosclerotic occlusive di-sease (LEASO) in ...
ZHAO Rui, ZHAO Fule, OU Minghui
doaj   +1 more source

Interleukin-6 production by thyroid epithelial cells. Enhancement by interleukin-1

, 1991
Interleukin-1 is a potent inhibitor of thyroglobulin and cAMP production in human thyroid cells and the inhibitory effect is enhanced by tumor necrosis factor-α and interferon-β In the present study secondary cultures of human thyroid cells produced ...
Diamant, Marcus, Kayser, Lars, Feldt-Rassmussen, Ulla, Bech, Karine, Rasmussen, Åse Krogh   +4 more
core   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes

Journal of Pharmacological Sciences, 2006
UTP causes interleukin (IL)-6 production via mRNA expression through P2Y2/P2Y4 receptors in human HaCaT keratinocytes. In the present study, we analyzed the mechanism of UTP-induced IL-6 production in these cells.
Daisaku Kobayashi, Satoko Ohkubo, Norimichi Nakahata   +2 more
doaj   +1 more source

Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension

, 2019
Interleukin-6 (IL-6) is a pleotropic cytokine that signals through the membrane-bound IL-6 receptor (mIL-6R) to induce antiinflammatory(‘‘classic-signaling’’) responses.
Lindsay M. Herbert (4217809), Nikki L. Jernigan (4217824), Laura Gonzalez bosc (758309), Tamara A Howard (6417176), Levi Maston (758310), Wieslawa Giermakowska (3710512), Juan M. Ramiro Diaz (4529206), Anna A. Maurice (6417177), David T Jones (59396), Thomas C. Resta (4217812)   +9 more
core   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source