Results 81 to 90 of about 382,334 (303)

EXPERIENCE WITH TOCILIZUMAB, AN INTERLEUKIN 6 INHIBITOR, USED FOR THE TREATMENT OF GIANT CELL ARTERITIS WITH SEVERE COMORBIDITY

Научно-практическая ревматология, 2018
Giant cell arteritis (GCA), formerly known as Horton's disease, is among the most common diseases from a group of systemic vasculitides; its clinical significance is complemented with the potential involvement of the coronary arteries, aorta, and cranial
T. V. Beketova, M. A. Ushakova, N. Yu. Nikishina, A. N. Khelkovskaya-Sergeeva, E. V. Nikolaeva, E. G. Sazhina, T. M. Novoselova, E. L. Nasonov   +7 more
doaj   +1 more source

CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease

Nature Communications, 2022
Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab.
Sheila K. Pierson, Laura Katz, Reece Williams, Melanie Mumau, Michael Gonzalez, Stacy Guzman, Ayelet Rubenstein, Ana B. Oromendia, Philip Beineke, Alexander Fosså, Frits van Rhee, David C. Fajgenbaum   +11 more
doaj   +1 more source

Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus [PDF]

, 1998
Recently, myxoma virus was shown to encode an additional member of the serpin superfamily. The viral gene, called serp2, was cloned, and the Serp2 protein was shown to specifically bind to interleukin-1beta (IL-1beta)-converting enzyme (ICE), thus ...
Messud-Petit, Frédérique, Py, Robert, Gelfi, Jacqueline, Amardeilh, Marie France, Bertagnoli, Stéphane, Sutter, Gerd, Delverdier, Maxence   +6 more
core  

Taurolidine reduces the tumor stimulating cytokine interleukin-1beta in patients with resectable gastrointestinal cancer : a multicentre prospective randomized trial

, 2009
Background The effect of additional treatment strategies with antineoplastic agents on intraperitoneal tumor stimulating interleukin levels are unclear.
Willems Wilhelm, Scheele, Johannes, Gutt, Carsten Nils, Jacobi, Christoph A., Scheele Johannes, Menenakos Charalambos, Müller, Joachim M., Mueller Joachim M, Menenakos, Charalambos, Braumann Chris, Jacobi Christoph A, Willems, Wilhelm, Gutt Carsten N, Braumann, Chris   +13 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Mecanismos envolvidos na hipernocicepção mecânica muscular induzida pela Interleucina-6 (IL-6) em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos na ...
Manjavachi, Marianne Neves
core  

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Acetaminophen changes the RNA m6A levels and m6A-related proteins expression in IL-1β-treated chondrocyte cells

BMC Molecular and Cell Biology, 2022
Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao, Yan Li, Zijin Liu, Dong Wang, Huawu Zhang   +4 more
doaj   +1 more source

Systemic inflammation and residual viraemia in HIV-positive adults on protease inhibitor monotherapy: a cross-sectional study.

, 2015
Increased levels of markers of systemic inflammation have been associated with serious non-AIDS events even in patients on fully suppressive antiretroviral therapy.
Richard Gilson, McKendry, A, Gilson, R, Ana Milinkovic, Arenas-Pinto, A, Maini, M, Milinkovic, A, Anna McKendry, Peppa, D, Alejandro Arenas-Pinto, Dimitra Peppa, Mala Maini   +11 more
core   +1 more source