Results 241 to 250 of about 1,282,878 (301)
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Fusion Protein of Interleukin-6 and Interleukin-6 Receptor without a Polypeptide Linker
Journal of Bioscience and Bioengineering, 2003FP6, a novel recombinant fusion protein of interleukin-6 (IL-6) and IL-6 receptor (IL-6R), was prepared in the methylotrophic yeast Pichia pastoris. This protein was a potent activator of a cell surface transducing glycoprotein, gp130 and is a potential therapeutical reagent in the hemopoietic field. A linker is generally thought to be required for two
Kiyoshi, Yasukawa +8 more
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Therapeutic Targeting of the Interleukin-6 Receptor
Annual Review of Pharmacology and Toxicology, 2012Interleukin (IL)-6 is a typical cytokine featuring redundancy and pleiotropic activity. It contributes to host defense against pathogens, but dysregulation of IL-6 production plays a significant pathological role in various autoimmune and inflammatory diseases.
Toshio, Tanaka +2 more
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European cytokine network, 1998
An sIL-6R/IL-6 chimera, directly fusing the natural forms of soluble IL-6 receptor and IL-6, as found in human body fluids, was produced in transfected human cells. The secreted p85 glycoprotein was active at a concentration of 120 pM to produce growth-arrest and spindleoid differentiation of murine melanoma F10.9 cells, which do not respond to IL-6 ...
J, Chebath +10 more
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An sIL-6R/IL-6 chimera, directly fusing the natural forms of soluble IL-6 receptor and IL-6, as found in human body fluids, was produced in transfected human cells. The secreted p85 glycoprotein was active at a concentration of 120 pM to produce growth-arrest and spindleoid differentiation of murine melanoma F10.9 cells, which do not respond to IL-6 ...
J, Chebath +10 more
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The role of the interleukin (IL)-6/IL-6 receptor axis in cancer.
Biochemical Society Transactions, 2018Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal' in a manner that is facilitated by its binding to a soluble derivative ...
M. Taher, David M. Davies, J. Maher
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Acta Diabetologica, 1999
We evaluated the relationship between plasma fibrinogen concentration and the serum levels of interleukin-6 (IL-6), its soluble receptor, and their complex in patients with type 2 diabetes mellitus. The study comprised 57 patients with type 2 diabetes and 15 normal healthy controls.
S, Kado, T, Nagase, N, Nagata
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We evaluated the relationship between plasma fibrinogen concentration and the serum levels of interleukin-6 (IL-6), its soluble receptor, and their complex in patients with type 2 diabetes mellitus. The study comprised 57 patients with type 2 diabetes and 15 normal healthy controls.
S, Kado, T, Nagase, N, Nagata
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Interleukin‐6 and Interleukin‐6 Receptor are Expressed by Cultured Glomerular Epithelial Cells
Scandinavian Journal of Immunology, 1994Interleukin‐6 (IL‐6) has been extensively studied in mesangial cells but little is known about the expression of this cytokine and its receptor in glomerular epithelial cells (GEC). IL‐6 was detected in the culture supernatants of human GEC and its production was enhanced in time and dose dependent manner by lipopolysaccharide (LPS), interleukin‐1β (IL‐
A, Moutabarrik +2 more
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Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain
Neuroscience Letters, 1992The cytokine interleukin 6 (IL6) has several effects on the central nervous system in addition to the well established regulation of the acute phase inflammatory response. Therefore, the distribution of IL6- and IL6 receptor mRNA in the rat brain has been investigated by in situ hybridization using [35S]-labeled oligonucleotides.
B, Schöbitz +2 more
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Expression of interleukin-6 and interleukin-6 receptors in human granulosa lutein cells
Molecular Human Reproduction, 1998Cytokines are important regulators of reproductive functions. Significant amounts of interleukin-6 (IL-6) have been detected in the serum and ascites of patients with ovarian hyperstimulation syndrome (OHSS). These findings suggest the involvement of IL-6 as a mediator in the pathogenesis of OHSS.
Keck, Christoph +5 more
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Serum Interleukin-6 Soluble Receptor in Relation to Interleukin-6 in Stroke Patients
Journal of Molecular Neuroscience, 2004Cerebral ischemia triggers interleukin-6 (IL-6) release into blood. IL-6 is a key mediator of acute phase reaction. Markers of acute phase reaction (C-reactive protein, fibrinogen, fever) have been linked to poor prognosis in stroke patients. Interleukin-6 soluble receptor (sIL-6R) can potentiate IL-6 pro-inflammatory activity.
Tomasz, Dziedzic +4 more
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Autocrine Interleukin-6/Interleukin-6 Receptor Stimulation in Non–Small-Cell Lung Cancer
Clinical Lung Cancer, 2006Autocrine growth factor stimulation resulting in growth self-sufficiency is a hallmark of cancer. Classically, non-small-cell lung cancer (NSCLC) cells have autocrine epidermal growth factor stimulation through coexpression of receptors and ligands. In addition to epidermal growth factor receptor and other growth factor ligand-receptor autocrine loops,
Eric B, Haura +2 more
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