Results 221 to 230 of about 467,392 (261)
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Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease
Journal of Gastroenterology and Hepatology, 1999Interleukin-6 (IL-6) has multiple immunological effects on a wide variety of cells and tissues. The expression of IL-6 and IL-6 receptor (IL-6R) may be important to the pathogenesis of inflammatory bowel disease (IBD).In the present study, we examined whether mucosal IL-6 and soluble IL-6R were associated with the pathophysiology of IBD using the ...
T, Hosokawa +10 more
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Leukemia & Lymphoma, 1997
Interluekin-6 (IL-6)/IL-6 receptor (IL-6R) play a major role in autocrine/paracrine growth regulation of myeloma cells and are the central mediators for bone destruction and other systemic manifestations of multiple myeloma. Modulation of the IL-6/IL-6R cytokine loop thus represents a rational therapeutic approach.
Y H, Chen +4 more
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Interluekin-6 (IL-6)/IL-6 receptor (IL-6R) play a major role in autocrine/paracrine growth regulation of myeloma cells and are the central mediators for bone destruction and other systemic manifestations of multiple myeloma. Modulation of the IL-6/IL-6R cytokine loop thus represents a rational therapeutic approach.
Y H, Chen +4 more
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The soluble interleukin-6 receptor and related proteins
Best Practice & Research Clinical Endocrinology & Metabolism, 2015Interleukin-6 is a cytokine involved in the regulation of the immune system and the central nervous system. Interleukin-6 binds to an interleukin-6 receptor, and then associates with a dimer of the ubiquitously expressed gp130 receptor subunit, which initiates intracellular signaling.
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Cellular Localization of Interleukin 6 mRNA and Interleukin 6 Receptor mRNA in Rat Brain
European Journal of Neuroscience, 1993AbstractThe distribution of interleukin 6 (IL‐6) mRNA and IL‐6 receptor (IL‐6R) mRNA in the brain of adult male rats was studied at the light microscope level by in situ hybridization histochemistry using 35S‐labelled oligonucleotides. The transcripts of both genes were localized in the pyramidal neurons and in the granular neurons of the hippocampus ...
B, Schöbitz +3 more
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Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.
Cancer research, 1991We have probed for the presence of interleukin 6 (IL6) receptors in prostatic carcinoma cell lines (LNCaP, DU 145, and PC3) by examining their sensitivity to the cytotoxic effects of a chimeric toxin composed of IL6 and Pseudomonas exotoxin (PE). All three cell lines were killed by IL6-PE66(4)Glu, a version of IL6-PE in which the binding domain of ...
C B, Siegall +4 more
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Tocilizumab: The first interleukin-6-receptor inhibitor
American Journal of Health-System Pharmacy, 2008The pharmacology, pharmacokinetics, clinical efficacy, safety, and role of tocilizumab in rheumatoid arthritis (RA) are reviewed.Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R).
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Interleukin-6 Receptor and Signals
Chemical immunology, 1992Tetsuya Taga +10 more
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European cytokine network, 1998
An sIL-6R/IL-6 chimera, directly fusing the natural forms of soluble IL-6 receptor and IL-6, as found in human body fluids, was produced in transfected human cells. The secreted p85 glycoprotein was active at a concentration of 120 pM to produce growth-arrest and spindleoid differentiation of murine melanoma F10.9 cells, which do not respond to IL-6 ...
J, Chebath +10 more
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An sIL-6R/IL-6 chimera, directly fusing the natural forms of soluble IL-6 receptor and IL-6, as found in human body fluids, was produced in transfected human cells. The secreted p85 glycoprotein was active at a concentration of 120 pM to produce growth-arrest and spindleoid differentiation of murine melanoma F10.9 cells, which do not respond to IL-6 ...
J, Chebath +10 more
openaire +1 more source
The Soluble Interleukin‐6 Receptora
Annals of the New York Academy of Sciences, 1995S, Rose-John +3 more
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