Results 201 to 210 of about 467,392 (261)

Therapeutic Targeting of the Interleukin-6 Receptor

Annual Review of Pharmacology and Toxicology, 2012
Interleukin (IL)-6 is a typical cytokine featuring redundancy and pleiotropic activity. It contributes to host defense against pathogens, but dysregulation of IL-6 production plays a significant pathological role in various autoimmune and inflammatory diseases.
Toshio, Tanaka, Masashi, Narazaki, Tadamitsu, Kishimoto   +2 more
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Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors

Journal of Neuro-Oncology, 1994
Interleukin-6 (IL-6) is a multifunctional cytokine which plays a role in the stimulation, inhibition, differentiation, and regulation of cell growth. IL-6 has been shown to act as an autocrine growth factor in several tumors, and is expressed by a variety of tumors. IL-6 also exhibits a regulatory role in the hypothalamo-pituitary axis.
A R, Rezai, A, Rezai, O, Martínez-Maza, M, Vander-Meyden, M H, Weiss   +4 more
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Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease

Neuroscience Letters, 1998
Serum levels of interleukin-6 (IL-6) and interleukin-6 soluble receptor (IL-6sR) were measured in 41 patients (23 female and 18 male, mean age 72.5 years) with Alzheimer's disease (AD) and in 32 controls (14 women and 18 men, mean age 69.2 years) using enzyme-linked immunosorbent assays (ELISA).
P, Angelis, S, Scharf, A, Mander, F, Vajda, N, Christophidis   +4 more
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Fusion Protein of Interleukin-6 and Interleukin-6 Receptor without a Polypeptide Linker

Journal of Bioscience and Bioengineering, 2003
FP6, a novel recombinant fusion protein of interleukin-6 (IL-6) and IL-6 receptor (IL-6R), was prepared in the methylotrophic yeast Pichia pastoris. This protein was a potent activator of a cell surface transducing glycoprotein, gp130 and is a potential therapeutical reagent in the hemopoietic field. A linker is generally thought to be required for two
Kiyoshi, Yasukawa, Shigeo, Tsuchiya, Teiji, Ekida, Hiroshi, Iida, Teruhiko, Ide, Daisuke, Miki, Harutaka, Yagame, Keiichi, Murayama, Takahiko, Ishiguro   +8 more
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Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

Neuroscience Letters, 1992
The cytokine interleukin 6 (IL6) has several effects on the central nervous system in addition to the well established regulation of the acute phase inflammatory response. Therefore, the distribution of IL6- and IL6 receptor mRNA in the rat brain has been investigated by in situ hybridization using [35S]-labeled oligonucleotides.
B, Schöbitz, D A, Voorhuis, E R, De Kloet   +2 more
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Interleukin-6 and its receptor in autoimmunity

Journal of Autoimmunity, 1992
Interleukin-6 (IL-6) is a multifunctional cytokine which acts on a wide variety of cells, regulating immune response, acute phase reaction and hematopoiesis. In accordance with its pleiotropic functions, IL-6 is indicated to be involved in the pathogenesis of several diseases including autoimmunities, lymphoid malignancies and inflammations.
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Hodgkin and Reed-Sternberg Cells Express Interleukin 6 and Interleukin 6 Receptors

Leukemia & Lymphoma, 1992
Interleukin 6 (IL-6) is a pleiotropic lymphokine which can stimulate a variety of cells including B and T lymphocytes. It has been suggested that IL-6 plays a crucial role in several diseases such as human plasmacytoma, cardiac myxoma or Castleman's Disease by autocrine or paracrine stimulation.
H, Tesch, M, Jücker, S, Klein, H, Abts, A, Günther, G R, Krueger, V, Diehl   +6 more
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Immunotherapeutic Interleukin-6 or Interleukin-6 Receptor Blockade in Cancer: Challenges and Opportunities

Current Medicinal Chemistry, 2018
Interleukin 6 (IL-6), a well-known pro-inflammatory cytokine with pleiotropic activity is a central player in chronic inflammatory diseases including cancers. Therefore, blockade of the IL-6 signalling pathway has become a target for the therapy of diverse cancers such as multicentric Castleman’s disease (CD), multiple myeloma and solid tumours ...
Nirmala Chandralega, Kampan, Sue D, Xiang, Orla M, McNally, Andrew N, Stephens, Michael A, Quinn, Magdalena, Plebanski   +5 more
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Anti-Interleukin-6 and Soluble Interleukin-6 Receptor in Systemic Lupus Erythematosus

Lupus, 1994
IL-6, soluble IL-6 receptor and IgG with anti-IL-6 activity were measured in the plasma of 14 lupus patients and 10 normal subjects. The capacity of peripheral blood mononuclear cells to spontaneously produce IL-6 in vitro was also measured. Our results indicate that IL-6 plasma levels in patient plasma as measured by ELISA were not different from ...
M, Evans, N I, Abdou
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Serum Interleukin-6, Soluble Interleukin-6 Receptor and Crohn’s Disease Activity

Digestive Diseases and Sciences, 2007
The relationship between plasma interleukin-6 (IL-6) concentration and its soluble receptor in Crohn's disease (CD) is not well elucidated. Twenty healthy volunteers and 94 consecutive patients with CD (44 in relapse and 50 in remission) were studied. Plasma IL-6 concentrations in patients with active disease [80 +/- 9 pg/ml; mean +/- standard error of
Stéphane, Nancey, Nadim, Hamzaoui, Driffa, Moussata, Ivan, Graber, Jacques, Bienvenu, Bernard, Flourie   +5 more
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