A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
EXPRESSION OF CONCERN: Selective Upregulation of Interleukin-8 by Human Rhabdomyosarcomas in Response to Hypoxia: Therapeutic Implications. [PDF]
europepmc +1 more source
Interleukin-8 Overexpressing Collagen Microgel-Based Cellular Microtissue Accelerates the Healing of Diabetic Foot Ulcers. [PDF]
Chung H, Jang WY, Choi JK, Kim SH.
europepmc +1 more source
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song +5 more
wiley +1 more source
AMY109, an interleukin-8 antibody, as a potential target for endometriosis treatment: a commentary. [PDF]
Wilson TR, Burns KA.
europepmc +1 more source
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou +11 more
wiley +1 more source
Comments on "Safety and pharmacology of AMY109, a long-acting anti-interleukin-8 antibody, for endometriosis: a double-blind, randomized phase 1 trial". [PDF]
Dokania S, Aphale P, Shekhar H.
europepmc +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Association between serum interleukin 8 levels and cardiovascular events in patients with chronic kidney disease. [PDF]
Pluquet M +8 more
europepmc +1 more source

