Results 101 to 110 of about 973,470 (302)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Interleukin signaling in the regulation of natural killer cells biology in breast cancer

Frontiers in Immunology
In the field of breast cancer treatment, the immunotherapy involving natural killer (NK) cells is increasingly highlighting its distinct potential and significance.
Jiachi Xu, Jiachi Xu, Hongyu Gao, Hongyu Gao, Muhammad Salman Azhar, Haifan Xu, Siyuan Chen, Mingcan Li, Xinxi Ni, Ting Yan, Hui Zhou, Qian Long, Qian Long, Wenjun Yi, Wenjun Yi   +14 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability [PDF]

, 2014
Exposure to particulate matter (PM) has been associated with an increase in many inflammatory markers, including interleukin 6 (IL6). Air pollution exposure has also been suggested to induce an imbalance in the autonomic nervous system (ANS), such as a ...
Probst-Hensch, Nicole, Kronenberg, Florian, Imboden, Medea, Medea Imboden, Adam, Martin, Carballo, David, Künzli, Nino, David Carballo, Emmanuel Schaffner, Martin Adam, Eva Boes, Nino Künzli, Boes, Eva, Jean-Michel Gaspoz, Schaffner, Emmanuel, Harish Chandra Phuleria, Florian Kronenberg, Nicole Probst-Hensch, Phuleria, Harish Chandra, Gaspoz, Jean-Michel   +19 more
core   +1 more source

Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice

Open Veterinary Journal
Background: The fungus comb is a unique structure inside termites' nests that facilitates the growth of Termitomyces sp. as a nutrient source for the termites. It is known to possess immunomodulatory properties that boost the immune system.
Hermawan Susanto, Jeferson Caesario, Decsa Medika Hertanto, Ketut Sudiana, Kukuh Dwiputra Hernugrahanto, Dwikora Novembri Utomo, Nicolaas Cyrillus Budhiparama, Ahmad Dzulfikri Nurhan, Mahardian Rahmadi, Dodi Nandika, Lina Karlinasari, Arinana Arinana, Irmanida Batubara, Lucia Dhiantika Witasari, Yanti Rachmayanti, Dikhi Firmasyah, Sairah Abdul Karim, Indang Ariati Ariffin, Djoko Santoso   +18 more
doaj   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV₁.

, 2016
Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV1.
Ting Liu (45625), Fa-Ping Wang (3358667), Hui Mao (115181), Zhu Lan (3358673), Su-Yun Li (3358670)   +4 more
core   +1 more source

Investigation the concentration of interleukin-6, interleukin-10, and vitamin D in diabetic patients with covid-19 hospitalized in the intensive care unit

Fiyz̤, 2023
Background: Anti-cytokine considerations and other treatments in covid-19 patients with a history of diabetes can play an important role in preventing mortality.
Farnaz Seifi-Skishahr , Maghsoud Nabilpour   +1 more
doaj  

Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study

Arthritis Care &Research, EarlyView.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023.
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

Receptors for interleukin 4, interleukin 5 and interleukin 6.

Annali dell'Istituto superiore di sanita, 1991
cDNA encoding IL-4, IL-5 and IL-6 have been isolated and the availability of recombinant proteins allowed the demonstration of the pleiotropic effects of these cytokines. IL-4, IL-5 and IL-6 bind to high affinity receptors (Kd = 1-6 x 10(-10) M) expressed in low numbers on cells. The IL-4R is expressed on virtually every cell type whereas the IL-6R and
J, Banchereau, J P, Galizzi
openaire   +1 more source