Results 241 to 250 of about 1,122,542 (370)

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Advanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin   +8 more
wiley   +1 more source

Utility of Cytokine Biomarkers for the Diagnosis of Pediatric Pyogenic Musculoskeletal Infections. [PDF]

Open Forum Infect Dis
Geanacopoulos AT, Lee PY, Lyons TW, Brodeur KE, Aresco RK, Monuteaux M, Kaplan RL, Cruz AT, Nigrovic PA, Nigrovic LE.   +9 more
europepmc   +1 more source

Suppression of antigen-specific interleukin 2 production in the MRL/MpJ-lpr/lpr mouse. [PDF]

, 1986
S J Naides
openalex   +1 more source

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source

Single nucleotide polymorphisms, gene expression and evaluation of immunological, antioxidant, and pathological parameters associated with bacterial pneumonia in Barki sheep. [PDF]

Ir Vet J
Sayed AE, Hafez A, Ateya A, Darwish A, Tahoun A.   +4 more
europepmc   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Interleukin-6, Tocilizumab and Atherosclerosis. Comment on Gerasimova et al. Interleukin-6: Cardiovascular Aspects of Long-Term Cytokine Suppression in Patients with Rheumatoid Arthritis. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 12425. [PDF]

Int J Mol Sci
Saleh C, Budincevic H.
europepmc   +1 more source

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia. [PDF]

, 1989
Yuman Fong, Kevin J. Tracey, Lyle L. Moldawer, David Hesse, K Manogue, J S Kenney, A T Lee, George Kuo, A. C. Allison, S. F. Lowry   +9 more
openalex   +1 more source

Dimethyl Itaconate Alleviates Escherichia coli‐Induced Endometritis Through the Guanosine‐CXCL14 Axis via Increasing the Abundance of norank_f_Muribaculaceae

Advanced Science, EarlyView.
The research findings indicate that dimethyl itaconate (DI) alleviates Escherichia coli (E. coli) induced endometritis by modulating the gut microbiota and enriching the abundance of norank_f_Muribaculaceae, thereby increasing the production of guanosine.
Yuhang He, Jiapei Cai, Xufeng Xie, Xinyu Zhang, Linkai Qu, Jiuxi Liu, Yongguo Cao   +6 more
wiley   +1 more source

Lymphocyte Subsets and Cytokine Changes in Women With Gestational Diabetes Mellitus: A Systematic Review. [PDF]

J Diabetes Res
Yu W, Miao H, Gong Y.
europepmc   +1 more source